使用非甾体抗炎药的人群患头颈部鳞状细胞癌的风险降低。
Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.
作者信息
Ahmadi Neda, Goldman Radoslav, Seillier-Moiseiwitsch Françoise, Noone Anne-Michelle, Kosti Ourania, Davidson Bruce J
机构信息
Department of Otolaryngology Head and Neck Surgery, Georgetown University Hospital, Washington, DC 20007, USA.
出版信息
Int J Otolaryngol. 2010;2010:424161. doi: 10.1155/2010/424161. Epub 2010 Jun 3.
Abstract
We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.
摘要
我们通过对71例新发头颈鳞状细胞癌（HNSCC）病例和相同数量的健康对照者进行标准化问卷调查，开展了一项病例对照研究，以评估非甾体抗炎药（NSAID）在HNSCC中的化学预防作用。使用NSAID与HNSCC发病风险降低75%相关。NSAID使用频率与显著降低风险相关。将分析局限于阿司匹林使用者，发现HNSCC发病风险显著降低了90%。本研究为NSAID使用者，特别是阿司匹林使用者中HNSCC发病风险显著降低提供了证据。
相似文献
1
Decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs.使用非甾体抗炎药的人群患头颈部鳞状细胞癌的风险降低。
Int J Otolaryngol. 2010;2010:424161. doi: 10.1155/2010/424161. Epub 2010 Jun 3.
2
Association of Nonsteroidal Anti-inflammatory Drug Use With Survival in Patients With Squamous Cell Carcinoma of the Head and Neck Treated With Chemoradiation Therapy.非甾体抗炎药的使用与接受放化疗的头颈部鳞状细胞癌患者生存的关系。
JAMA Netw Open. 2020 Jun 1;3(6):e207199. doi: 10.1001/jamanetworkopen.2020.7199.
3
Aspirin use and head and neck cancer survival: an observational study of 11,623 person-years follow-up.阿司匹林的使用与头颈癌生存率：一项为期11623人年随访的观察性研究。
Int J Clin Oncol. 2018 Feb;23(1):52-58. doi: 10.1007/s10147-017-1165-3. Epub 2017 Jul 19.
4
Nonsteroidal anti-inflammatory drugs and the risk of nonmelanoma skin cancer.非甾体抗炎药与非黑色素瘤皮肤癌的风险
Int J Cancer. 2015 Jul 1;137(1):144-53. doi: 10.1002/ijc.29357. Epub 2014 Dec 3.
5
Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for -altered head and neck cancer.使用非甾体抗炎药可预测头颈部癌症患者的生存率提高。
J Exp Med. 2019 Feb 4;216(2):419-427. doi: 10.1084/jem.20181936. Epub 2019 Jan 25.
6
Nonsteroidal anti-inflammatory drugs exposure and the central nervous system.非甾体抗炎药暴露与中枢神经系统
Handb Clin Neurol. 2014;119:577-84. doi: 10.1016/B978-0-7020-4086-3.00038-2.
7
Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomized study.服用阿司匹林3年后使用非甾体抗炎药与结直肠腺瘤风险：一项随机研究的观察性随访
J Natl Cancer Inst. 2009 Feb 18;101(4):267-76. doi: 10.1093/jnci/djn484. Epub 2009 Feb 10.
8
Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.阿司匹林及其他非甾体抗炎药的使用与食管癌和胃癌风险
Cancer Epidemiol Biomarkers Prev. 1998 Feb;7(2):97-102.
9
Association of nonsteroidal anti-inflammatory drugs and aspirin use and the risk of head and neck cancers: a meta-analysis of observational studies.非甾体抗炎药和阿司匹林的使用与头颈癌风险的关联：观察性研究的荟萃分析
Oncotarget. 2016 Oct 4;7(40):65196-65207. doi: 10.18632/oncotarget.11239.
10
A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence.一项关于阿司匹林及其他非甾体抗炎药与前列腺癌发病率的大型队列研究。
J Natl Cancer Inst. 2005 Jul 6;97(13):975-80. doi: 10.1093/jnci/dji173.
引用本文的文献
1
Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited.PIK3CA 突变型结直肠癌的阿司匹林敏感性：潜在机制再探讨。
Cell Mol Life Sci. 2022 Jul 2;79(7):393. doi: 10.1007/s00018-022-04430-y.
2
NSAIDs Overcome Mutation-Mediated Resistance to EGFR Inhibition in Head and Neck Cancer Preclinical Models.非甾体抗炎药克服头颈部癌临床前模型中由突变介导的对表皮生长因子受体抑制的耐药性。
Cancers (Basel). 2022 Jan 20;14(3):506. doi: 10.3390/cancers14030506.
3
Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity.前列腺素E2与癌症：对肿瘤进展和免疫的洞察
Biology (Basel). 2020 Dec 1;9(12):434. doi: 10.3390/biology9120434.
4
Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4.表皮生长因子诱导的 COX-2 通过上调血管生成素样蛋白 4 调节头颈部鳞状细胞癌的转移。
Cancer Sci. 2020 Jun;111(6):2004-2015. doi: 10.1111/cas.14400. Epub 2020 Apr 18.
5
Gene targets of sulforaphane in head and neck squamous cell carcinoma.硫代葡萄糖苷萝卜硫素对头颈部鳞状细胞癌的基因靶点。
Mol Med Rep. 2019 Dec;20(6):5335-5344. doi: 10.3892/mmr.2019.10766. Epub 2019 Oct 23.
6
NSAID therapy for PIK3CA-Altered colorectal, breast, and head and neck cancer.PIK3CA 改变的结直肠癌、乳腺癌和头颈部癌症的 NSAID 治疗。
Adv Biol Regul. 2020 Jan;75:100653. doi: 10.1016/j.jbior.2019.100653. Epub 2019 Sep 15.
7
Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for -altered head and neck cancer.使用非甾体抗炎药可预测头颈部癌症患者的生存率提高。
J Exp Med. 2019 Feb 4;216(2):419-427. doi: 10.1084/jem.20181936. Epub 2019 Jan 25.
8
Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?头颈部癌症的化学预防：只有一种方法吗？
Biomed Res Int. 2018 Sep 25;2018:9051854. doi: 10.1155/2018/9051854. eCollection 2018.
9
Aspirin is Involved in the Cell Cycle Arrest, Apoptosis, Cell Migration, and Invasion of Oral Squamous Cell Carcinoma.阿司匹林参与口腔鳞状细胞癌的细胞周期停滞、细胞凋亡、细胞迁移和侵袭。
Int J Mol Sci. 2018 Jul 12;19(7):2029. doi: 10.3390/ijms19072029.
10
Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.阿司匹林使用与癌症风险的关联：观察性研究的荟萃分析。
BMC Cancer. 2018 Mar 13;18(1):288. doi: 10.1186/s12885-018-4156-5.
本文引用的文献
1
Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study.基于人群的病例对照研究中，选择性环氧化酶-2 抑制剂、非选择性非甾体抗炎药处方与乳腺癌风险。
Breast Cancer Res. 2010;12(2):R15. doi: 10.1186/bcr2482. Epub 2010 Mar 1.
2
Aspirin is not chemoprotective for Barrett's adenocarcinoma of the oesophagus in multicentre cohort.在多中心队列研究中，阿司匹林对食管巴雷特腺癌无化学保护作用。
Eur J Cancer Prev. 2009 Sep;18(5):381-4. doi: 10.1097/CEJ.0b013e32832e0955.
3
A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia.一项关于食管癌鳞状细胞癌或贲门腺癌切除术后服用阿司匹林患者术后生存情况的初步研究。
Ann Surg Oncol. 2009 May;16(5):1397-402. doi: 10.1245/s10434-009-0382-z. Epub 2009 Feb 25.
4
Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.阿司匹林用于结直肠腺瘤的化学预防：随机试验的荟萃分析
J Natl Cancer Inst. 2009 Feb 18;101(4):256-66. doi: 10.1093/jnci/djn485. Epub 2009 Feb 10.
5
Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis.非甾体抗炎药与胃和食管腺癌风险：一项队列研究及荟萃分析的结果
Br J Cancer. 2009 Feb 10;100(3):551-7. doi: 10.1038/sj.bjc.6604880. Epub 2009 Jan 20.
6
Cancer statistics, 2008.2008年癌症统计数据。
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96. doi: 10.3322/CA.2007.0010. Epub 2008 Feb 20.
7
Head and neck cancer recurrence and mortality in nonselective cyclooxygenase inhibitor users.非选择性环氧化酶抑制剂使用者的头颈癌复发与死亡率
Arch Otolaryngol Head Neck Surg. 2007 Jan;133(1):28-31. doi: 10.1001/archotol.133.1.28.
8
Chemoprevention of head and neck cancer with aspirin: a case-control study.阿司匹林对头颈部癌症的化学预防：一项病例对照研究。
Arch Otolaryngol Head Neck Surg. 2006 Nov;132(11):1231-6. doi: 10.1001/archotol.132.11.1231.
9
Aspirin and cancer risk: an updated quantitative review to 2005.阿司匹林与癌症风险：截至2005年的最新定量综述
Cancer Causes Control. 2006 Sep;17(7):871-88. doi: 10.1007/s10552-006-0033-7.
10
Socioeconomic effects of and risk factors for disability in long-term survivors of head and neck cancer.头颈癌长期幸存者残疾的社会经济影响及风险因素
Arch Otolaryngol Head Neck Surg. 2006 Jan;132(1):32-5. doi: 10.1001/archotol.132.1.32.
Zotero 插件