抑郁和焦虑症患者的弓形虫血清阳性率
Toxoplasma gondii seropositivity in patients with depressive and anxiety disorders.
作者信息
de Bles Nienke J, van der Does Juliette E H, Kortbeek Laetitia M, Hofhuis Agnetha, van Grootheest Gerard, Vollaard Albert M, Schoevers Robert A, van Hemert Albert M, Penninx Brenda W J H, Rius-Ottenheim Nathaly, Giltay Erik J
机构信息
Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
National Institute for Public Health and the Environment (RIVM), Centre for Disease Control the Netherlands, Bilthoven, the Netherlands.
出版信息
Brain Behav Immun Health. 2020 Dec 31;11:100197. doi: 10.1016/j.bbih.2020.100197. eCollection 2021 Feb.
INTRODUCTION
is an obligate intracellular parasite that is estimated to be carried by one-third of the world population. Latent infection has been linked to several neuropsychiatric mood disorders and behaviors. The aim of the present study was to examine whether seropositivity is associated with affective disorders, as well as with aggression reactivity and suicidal thoughts.
METHODS
In the Netherlands Study of Depression and Anxiety (NESDA), antibodies were assessed in patients with current depressive (n = 133), anxiety (n = 188), comorbid depressive and anxiety (n = 148), and remitted disorders (n = 889), as well as in healthy controls (n = 373) based on DSM-IV criteria. Seropositivity was analyzed in relation to disorder status, aggression reactivity and suicidal thoughts using multivariate analyses of covariance and regression analyses.
RESULTS
Participants were on average 51.2 years ( = 13.2), and 64.4% were female. Seropositivity was found in 673 participants (38.9%). A strong positive association between seropositivity and age was observed. No significant associations were found between seropositivity and disorder status, aggression reactivity and suicidal thoughts. The adjusted odds ratio (OR) for any remitted disorder versus controls was 1.13 (95% CI: 0.87-1.49), and for any current disorder versus controls was 0.94 (95% CI: 0.69-1.28).
CONCLUSIONS
No evidence was found for a relationship between affective disorders and infection in the current sample.
引言
[病原体名称]是一种专性细胞内寄生虫，据估计全球三分之一的人口携带该病原体。潜伏感染与多种神经精神性情绪障碍及行为有关。本研究的目的是检验血清阳性是否与情感障碍、攻击反应性和自杀念头相关。
方法
在荷兰抑郁与焦虑研究（NESDA）中，根据《精神疾病诊断与统计手册》第四版标准，对当前患有抑郁症（n = 133）、焦虑症（n = 188）、共病抑郁和焦虑症（n = 148）以及缓解期疾病（n = 889）的患者，以及健康对照者（n = 373）进行抗体检测。使用多变量协方差分析和回归分析，分析血清阳性与疾病状态、攻击反应性和自杀念头之间的关系。
结果
参与者平均年龄为51.2岁（标准差 = 13.2），64.4%为女性。673名参与者（38.9%）血清呈阳性。观察到血清阳性与年龄之间存在强正相关。未发现血清阳性与疾病状态、攻击反应性和自杀念头之间存在显著关联。任何缓解期疾病与对照组相比的校正比值比（OR）为1.13（95%置信区间：0.87 - 1.49），任何当前疾病与对照组相比的校正比值比为0.94（95%置信区间：0.69 - 1.28）。
结论
在当前样本中，未发现情感障碍与[病原体名称]感染之间存在关联的证据。
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