School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Org Biomol Chem. 2021 Oct 20;19(40):8701-8705. doi: 10.1039/d1ob01592c.
A general visible-light-promoted metal-free synthesis of secondary and tertiary thiocarbamates starting from thiosulfonates and -substituted formamides is developed. By employing rhodamine B as a photocatalyst and -butyl hydroperoxide (TBHP) as an oxidant, a wide scope of thiocarbamates can be obtained through direct thiolation of acyl C-H bonds under irradiation of blue light at room temperature for 12 h.
开发了一种通用的可见光促进的无金属合成方法，可从硫代磺酸盐和 -取代甲酰胺出发合成仲和叔硫代氨基甲酸酯。通过使用罗丹明 B 作为光催化剂和叔丁基过氧化氢 (TBHP) 作为氧化剂，在室温下用蓝光照射 12 小时，可以直接通过酰基 C-H 键的硫代化反应得到广泛的硫代氨基甲酸酯。
