大鼠体内可待因和吗啡的存在与形成。
Presence and formation of codeine and morphine in the rat.
作者信息
Donnerer J, Oka K, Brossi A, Rice K C, Spector S
出版信息
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4566-7. doi: 10.1073/pnas.83.12.4566.
Abstract
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to that used by the poppy plant, (+)-salutaridine, (-)-thebaine, and (-)-codeine were administered to rats intravenously. These compounds, which are intermediates in the synthesis of morphine in Papaver somniferum, caused a marked increase in the codeine and morphine levels in rat tissues. This provides evidence for a biosynthetic pathway to morphine in mammalians.
摘要
通过高效液相色谱法（HPLC）后的免疫测定法，在大鼠脑中鉴定出内源性可待因和吗啡。为了证明哺乳动物中存在一条类似于罂粟植物所使用的吗啡生物合成途径，将（+）-氢可酮、（-）-蒂巴因和（-）-可待因静脉注射给大鼠。这些化合物是罂粟中吗啡合成的中间体，导致大鼠组织中可待因和吗啡水平显著升高。这为哺乳动物中吗啡的生物合成途径提供了证据。
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本文引用的文献
1
2
INVESTIGATIONS ON THE BIOSYNTHESIS OF MORPHINE ALKALOIDS.吗啡生物碱生物合成的研究
J Chem Soc. 1965 Apr:2423-38. doi: 10.1039/jr9650002423.
3
A non-peptide morphine-like compound from brain.一种来自大脑的非肽类吗啡样化合物。
Life Sci. 1981 Feb 16;28(7):811-7. doi: 10.1016/0024-3205(81)90165-x.
4
Dynorphin is a specific endogenous ligand of the kappa opioid receptor.强啡肽是κ阿片受体的特异性内源性配体。
Science. 1982 Jan 22;215(4531):413-5. doi: 10.1126/science.6120570.
5
Quantitative determination of morphine in serum by radioimmunoassay.采用放射免疫分析法对血清中的吗啡进行定量测定。
J Pharmacol Exp Ther. 1971 Aug;178(2):253-8.
6
Isolation of morphine from toad skin.从蟾蜍皮肤中分离吗啡。
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1852-4. doi: 10.1073/pnas.82.6.1852.
7
Morphine and other opiates from beef brain and adrenal.来自牛脑和肾上腺的吗啡及其他阿片类药物。
Proc Natl Acad Sci U S A. 1985 Aug;82(15):5203-7. doi: 10.1073/pnas.82.15.5203.
8
Studies of the enterohepatic circulation of morphine in the rat.大鼠体内吗啡肝肠循环的研究。
J Pharmacol Exp Ther. 1975 Nov;195(2):303-10.
9
Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.抗体作为分离和鉴定生物活性物质的手段：中枢神经系统中存在一种非肽类、吗啡样化合物。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2132-6. doi: 10.1073/pnas.73.6.2132.
10
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