从蟾蜍皮肤中分离吗啡。
Isolation of morphine from toad skin.
作者信息
Oka K, Kantrowitz J D, Spector S
出版信息
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1852-4. doi: 10.1073/pnas.82.6.1852.
Abstract
A nonpeptide opioid was found in toad skin and purified to homogeneity by using HPLC with electrochemical detection. A nonpeptide opioid also was detected in bovine brain and adrenals as well as rabbit and rat skin, by reversed-phase HPLC following Sephadex G-15 column chromatography. The material in toad skin was identical to morphine by immunological, pharmacological, and physical chemical criteria.
摘要
在蟾蜍皮肤中发现了一种非肽类阿片样物质，并通过使用带有电化学检测的高效液相色谱法将其纯化至同质。通过葡聚糖凝胶G - 15柱色谱后的反相高效液相色谱法，在牛脑、肾上腺以及兔和大鼠的皮肤中也检测到了一种非肽类阿片样物质。根据免疫学、药理学和物理化学标准，蟾蜍皮肤中的物质与吗啡相同。
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