1University of Rhode Island, Kingston, Rhode Island.
2Rhode Island Hospital, Providence, Rhode Island.
Sr Care Pharm. 2021 Oct 1;36(10):489-492. doi: 10.4140/TCP.n.2021.489.
To identify the dietary supplements most commonly promoted online for brain health and to compare their major ingredients over 18 months. Mild cognitive impairment and Alzheimer's disease are increasing globally with few effective treatments available. Dietary supplements are widely promoted in the media and online for brain health and memory improvement despite minimal evidence of an actual effect. Incognito mode on Google Chrome was used to conduct four separate searches using the terms: memory supplement, brain health supplement, Alzheimer's supplement, and dementia supplement. The four separate searches for products were conducted through CVS, Walgreens, Walmart, GNC, Amazon, Yahoo, and Google. For each website, the top 10 supplement products and their ingredients were documented in August 2017 and again in January 2019. Of the four terms used, "memory supplement" and "brain health supplement" provided the most results. The most common products were Prevagen®, Procera®, and Neuro Health®. Amazon had the most repeated products in 2017 and 2019, while Google and CVS had the least. Focus Factor® appeared 11 times in 2019 compared with once in 2017. At both time points, the most commonly promoted products were proprietary blends of Ginkgo biloba, vitamins, particularly vitamin B12 and folic acid, huperzine-A, Bacopa monnieri, and phosphatidylserine. Though the 2017 and 2019 datasets showed diverse products, the primary ingredients were similar. These supplements have insufficient evidence of efficacy and are expensive. Health professionals must be knowledgeable about dietary supplements for brain health to appropriately counsel individuals.
为了确定在网上最常推广用于大脑健康的膳食补充剂，并比较它们在 18 个月内的主要成分。随着全球轻度认知障碍和阿尔茨海默病的发病率不断上升，目前可用的有效治疗方法却寥寥无几。尽管几乎没有实际效果的证据，但膳食补充剂仍在媒体和网上广泛宣传，用于大脑健康和记忆力改善。谷歌 Chrome 的隐身模式用于进行四项单独的搜索，使用的术语是：记忆补充剂、大脑健康补充剂、阿尔茨海默病补充剂和痴呆症补充剂。通过 CVS、Walgreens、Walmart、GNC、Amazon、Yahoo 和 Google 对四种产品进行了单独搜索。对于每个网站，都记录了 2017 年 8 月和 2019 年 1 月的前 10 种补充剂产品及其成分。在所使用的四个术语中，“记忆补充剂”和“大脑健康补充剂”提供了最多的结果。最常见的产品是 Prevagen®、Procera®和 Neuro Health®。2017 年和 2019 年，亚马逊的重复产品最多，而谷歌和 CVS 的重复产品最少。2019 年 Focus Factor®出现了 11 次，而 2017 年只有一次。在两个时间点，最常推广的产品都是银杏叶、维生素（特别是维生素 B12 和叶酸）、石杉碱甲、假马齿苋和磷脂酰丝氨酸的专利混合物。尽管 2017 年和 2019 年的数据集显示了不同的产品，但主要成分是相似的。这些补充剂的疗效证据不足，而且价格昂贵。医疗保健专业人员必须了解大脑健康的膳食补充剂，以便为个人提供适当的建议。
