Department of Urology, Miller School of Medicine, University of Miami, Miami, FL.
Department of Urology, Cleveland Clinic, Cleveland, OH.
Urology. 2020 Feb;136:133-141. doi: 10.1016/j.urology.2019.11.007. Epub 2019 Nov 17.
To study the level of evidence available for ingredients of popular over-the-counter male fertility supplements.
The top 17 male fertility supplements in the United States were identified from the most popular online retailers: A1 Supplements, Amazon, Vitamin Shoppe, and Walmart. Individual ingredients were identified for each supplement. The PUBMED and Cochrane online databases were reviewed for randomized controlled trials studying the efficacy of each ingredient. Each ingredient was categorized based on availability of evidence using an adapted version of the scoring system by the American Heart Association. Scores were assigned to each categorical level of evidence for each ingredient and a composite score for each supplement was calculated.
Ninety unique ingredients were identified. The 5 most commonly used ingredients were vitamin E, folic acid, zinc, vitamin C, and selenium whereas the 5 ingredients with most evidence were L-carnitine, Vitamin E, Vitamin C, CoQ10, and Zinc. In all, only 22% of ingredients used were found to have published evidence for improvement in semen parameters and only 17% of ingredients had data published showing a positive effect. Our evidence-based analysis demonstrated an average composite rating of 1.66 (on a scale to 5). Evolution 60 and Conception XR had the highest composite scores with 3.6 and 3.5, respectively.
Many male fertility supplements claim to improve fertility; however, their products are rarely backed by evidence and their efficacy remains unproven. Few ingredients used in popular fertility supplements have positive evidence in randomized clinical trials and should therefore be used cautiously.
研究热门非处方男性生育补充剂成分的现有证据水平。
从最受欢迎的在线零售商（A1 补充剂、亚马逊、维生素商店和沃尔玛）中确定美国排名前 17 的男性生育补充剂。为每种补充剂确定了个别成分。检索 PUBMED 和 Cochrane 在线数据库，以研究每种成分的功效的随机对照试验。根据美国心脏协会（American Heart Association）改编的评分系统，根据证据的可用性对每个成分进行分类。为每个成分的每个分类证据级别分配分数，并为每个补充剂计算综合分数。
确定了 90 种独特的成分。使用最广泛的 5 种成分是维生素 E、叶酸、锌、维生素 C 和硒，而证据最多的 5 种成分是左旋肉碱、维生素 E、维生素 C、辅酶 Q10 和锌。总共，只有 22%的使用成分被发现有改善精液参数的证据，只有 17%的成分有数据表明有积极的效果。我们的循证分析表明，平均综合评分 1.66（满分 5 分）。Evolution 60 和 Conception XR 的综合评分最高，分别为 3.6 和 3.5。
许多男性生育补充剂声称可以提高生育能力；然而，它们的产品很少有证据支持，其功效仍未得到证实。在流行的生育补充剂中使用的很少有成分有随机临床试验的阳性证据，因此应谨慎使用。
