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Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management.新型监测设备与机器学习技术的融合，实现可扩展的心血管管理。
Nat Rev Cardiol. 2021 Feb;18(2):75-91. doi: 10.1038/s41569-020-00445-9. Epub 2020 Oct 9.
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A rat model of complete atrioventricular block recapitulates clinical indices of bradycardia and provides a platform to test disease-modifying therapies.完全性房室传导阻滞大鼠模型重现了心动过缓的临床指标，并为测试疾病修饰疗法提供了一个平台。
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2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.2018年美国心脏病学会/美国心脏协会/心律学会关于心动过缓和心脏传导延迟患者评估与管理的指南：美国心脏病学会/美国心脏协会临床实践指南工作组及心律学会的报告
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8
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9
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细胞再生作为一种治疗心脏传导障碍的潜在策略。

Cellular regeneration as a potential strategy to treat cardiac conduction disorders.

机构信息

Cardiovascular Research Institute.

Department of Molecular Physiology and Biophysics.

出版信息

J Clin Invest. 2021 Oct 1;131(19). doi: 10.1172/JCI152185.

DOI:10.1172/JCI152185
PMID:34596049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8483745/
Abstract

Loss of atrioventricular conduction system (AVCS) cells due to either inherited or acquired deficits leads to conduction diseases, which can deteriorate into fatal cardiac arrhythmias and sudden death. In this issue of the JCI, Wang et al. constructed a mouse model of atrioventricular block (AVB) by inducing AVCS cell-specific injury using the Cx30.2 enhancer to drive expression of diphtheria toxin fragment A. AVCS cell ablation in adult mice led to irreversible AVB. jkjkIn contrast, AVCS cell injury in neonatal mice was followed by spontaneous recovery in a subset of mice, revealing a limited postnatal time window during which the regeneration of AVCS cells can occur as a result of cellular plasticity. This exciting study paves the way for future research into biological or cellular treatment approaches for cardiac conduction diseases by exploiting the regenerative potential of AVCS cells.

摘要

由于遗传或获得性缺陷导致房室传导系统 (AVCS) 细胞丧失，会引发传导疾病，进而恶化为致命性心律失常和心源性猝死。在本期 JCI 中，Wang 等人构建了一种房室传导阻滞 (AVB) 的小鼠模型，通过使用 Cx30.2 增强子驱动白喉毒素片段 A 的表达，特异性损伤 AVCS 细胞。成年小鼠的 AVCS 细胞消融导致不可逆的 AVB。相比之下，新生小鼠的 AVCS 细胞损伤随后在一部分小鼠中自发恢复，这揭示了一个有限的出生后时间窗口，在此期间，由于细胞可塑性，AVCS 细胞可能发生再生。这项令人兴奋的研究为利用 AVCS 细胞的再生潜力，探索心脏传导疾病的生物或细胞治疗方法奠定了基础。