Department of Neurosurgery, Yale University, New Haven, Connecticut 06510, United States.
Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06510, United States.
Nano Lett. 2021 Oct 13;21(19):8111-8118. doi: 10.1021/acs.nanolett.1c02459. Epub 2021 Oct 1.
Despite being promising, the clinical application of magnetic hyperthermia for brain cancer treatment is limited by the requirement of highly invasive intracranial injections. To overcome this limitation, here we report the development of gallic acid-coated magnetic nanoclovers (GA-MNCs), which allow not only for noninvasive delivery of magnetic hyperthermia but also for targeted delivery of systemic chemotherapy to brain tumors. GA-MNCs are composed of clover-shaped MNCs in the core, which can induce magnetic heat in high efficiency, and polymerized GA on the shell, which enables tumor vessel-targeting. We demonstrate that intravenous administration of GA-MNCs following alternating magnetic field exposure effectively inhibited brain cancer development and preferentially disrupted tumor vasculature, making it possible to efficiently deliver systemic chemotherapy for further improved efficacy. Due to the noninvasive nature and high efficiency in killing tumor cells and enhancing systemic drug delivery, GA-MNCs have the potential to be translated for improved treatment of brain cancer.
尽管具有广阔的前景，但磁性热疗在脑癌治疗中的临床应用受到高度侵袭性颅内注射的限制。为了克服这一限制，我们在此报告了一种没食子酸包覆的磁性纳米四叶草（GA-MNCs）的开发，它不仅允许非侵入性地输送磁性热疗，还可以靶向输送系统化疗药物至脑肿瘤。GA-MNCs 由核心中的四叶草形 MNCs 组成，能够高效地产生磁热，外壳上聚合的 GA 则使它能够靶向肿瘤血管。我们证明，在交变磁场暴露下静脉注射 GA-MNCs 可有效抑制脑癌发展并优先破坏肿瘤血管，从而可以有效地输送全身性化疗药物以进一步提高疗效。由于具有非侵入性和高效杀死肿瘤细胞以及增强全身药物输送的特性，GA-MNCs 有可能被转化为治疗脑癌的新方法。
