Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA.
Drug Alcohol Depend. 2021 Nov 1;228:109083. doi: 10.1016/j.drugalcdep.2021.109083. Epub 2021 Sep 21.
This study investigated the acute effects of exposure to pod-style e-cigarettes on subjective, behavioral, and physiological outcomes indicative of the potential to encourage vaping-naïve smokers to switch to e-cigarettes.
In a within-subject experiment, never-vaping adult smokers interested in trying e-cigarettes (n = 24) completed 4 laboratory visits following 16-hr tobacco abstinence. Visits involved controlled puffing from preferred brand cigarettes (OwnCig) or a standardized pod-style e-cigarette with either no nicotine (NoNic), nicotine freebase (NicFreebase; 0.5% nicotine concentration), or nicotine salt (NicSalt E-Cig; 2.8% concentration) solutions. Outcomes included smoking urge, mood, user experience, plasma nicotine, and a behavioral task assessing ability to delay smoking.
NoNic, NicFreebase, and NicSalt pod-style e-cigarettes were significantly less effective than OwnCig at reducing smoking urge and increasing plasma nicotine, positive affect, satisfying user experience ratings, and ability to delay smoking on the behavioral task. Differences among pod-style e-cigarette conditions were limited to: (a) NicFreebase (vs. NoNic) preferentially suppressed participants' urge to smoke to alleviate negative mood, (b) NicFreebase (vs. NicSalt) slightly preferentially increased plasma nicotine; and (c) NicFreebase and NicSalt (vs. NoNic) produced higher aversive user experience ratings.
In tobacco deprived smokers' initial vaping experience, controlled administration of certain pod-style e-cigarettes with 0.5% NicFreebase or 2.8% NicSalt may be deficient comparators to cigarettes in terms of their capacity to acutely improve mood, deliver nicotine, suppress smoking motivation, and offer a satisfying user experience. Future research is needed to test pod-style e-cigarettes with higher nicotine doses and confirm whether NicFreebase vs. NicSalt enhances nicotine absorption.
本研究旨在探究吸入 pod 式电子烟对初次使用电子烟者的主观、行为和生理结果的急性影响，这些结果提示我们此类产品可能会促使从未吸过电子烟的吸烟者转而使用电子烟。
在一项个体内实验中，24 名有兴趣尝试电子烟的从不吸电子烟的成年吸烟者在 16 小时的烟草戒断后完成了 4 次实验室访问。访问包括从他们喜欢的品牌香烟（OwnCig）或标准化的 pod 式电子烟中进行控制抽吸，这些电子烟分别含有无尼古丁（NoNic）、尼古丁游离碱（NicFreebase，0.5% 尼古丁浓度）或尼古丁盐（NicSalt E-Cig，2.8% 浓度）溶液。结果包括吸烟欲望、情绪、用户体验、血浆尼古丁以及一项评估延迟吸烟能力的行为任务。
NoNic、NicFreebase 和 NicSalt pod 式电子烟在降低吸烟欲望和增加血浆尼古丁、积极情绪、满足用户体验评分以及在行为任务中延迟吸烟的能力方面均显著逊于 OwnCig。电子烟条件之间的差异仅体现在：（a）NicFreebase（与 NoNic 相比）优先抑制了参与者吸烟的欲望，以缓解负面情绪；（b）NicFreebase（与 NicSalt 相比）略微优先增加了血浆尼古丁；以及（c）NicFreebase 和 NicSalt（与 NoNic 相比）产生了更高的令人不快的用户体验评分。
在烟草戒断的吸烟者首次尝试使用电子烟时，与香烟相比，某些含有 0.5% NicFreebase 或 2.8% NicSalt 的 pod 式电子烟在改善情绪、提供尼古丁、抑制吸烟动机和提供满意的用户体验方面可能存在缺陷。需要进一步研究含有更高尼古丁剂量的 pod 式电子烟，并确认 NicFreebase 与 NicSalt 相比是否能增强尼古丁的吸收。
