人胎儿脑生长调节素的特性：胰岛素样生长因子I变异体的鉴定。
Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.
作者信息
Sara V R, Carlsson-Skwirut C, Andersson C, Hall E, Sjögren B, Holmgren A, Jörnvall H
出版信息
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4904-7. doi: 10.1073/pnas.83.13.4904.
Abstract
A fetal form of somatomedin (insulin-like growth factor) that crossreacts in the fetal brain radioreceptor assay has been proposed to exist in humans. Using this assay to monitor activity during purification, we have isolated a variant form of insulin-like growth factor I (IGF-I) from human fetal brain tissue. The variant IGF-I showed potent crossreaction in the fetal brain radioreceptor assay and stimulated DNA synthesis in fetal brain cells in vitro. Structural analysis revealed the variant IGF-I to have a truncated NH2-terminal region compared to IGF-I isolated from serum. An additional peptide, which displayed less potent crossreaction in the fetal brain radioreceptor assay, was also isolated from the human fetal brain. Partial amino acid sequence analysis revealed identity to insulin-like growth factor II.
摘要
有人提出，人类体内存在一种在胎儿脑放射受体分析中发生交叉反应的胎儿形式的生长调节素（胰岛素样生长因子）。在纯化过程中，我们使用该分析方法监测活性，从人胎儿脑组织中分离出一种胰岛素样生长因子I（IGF-I）的变体形式。该变体IGF-I在胎儿脑放射受体分析中显示出强烈的交叉反应，并在体外刺激胎儿脑细胞中的DNA合成。结构分析表明，与从血清中分离出的IGF-I相比，该变体IGF-I的NH2末端区域被截断。还从人胎儿脑中分离出一种在胎儿脑放射受体分析中交叉反应较弱的额外肽段。部分氨基酸序列分析显示其与胰岛素样生长因子II相同。
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本文引用的文献
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