人胚胎生长调节素
Human embryonic somatomedin.
作者信息
Sara V R, Hall K, Rodeck C H, Wetterberg L
出版信息
Proc Natl Acad Sci U S A. 1981 May;78(5):3175-9. doi: 10.1073/pnas.78.5.3175.
Abstract
A radioreceptor assay utilizing human fetal brain plasma membrane as matrix and somatomedin A as ligand (fetal brain RRA-SMA) was developed. Increased levels of fetal brain RRA-SMA were found in the fetal circulation. The concentration was approximately 4-fold higher in the fetal as compared to the adult human. At birth, values fell within the adult range. In contrast, adult somatomedins determined by somatomedin radioimmunoassay were undetectable in the fetus and below the adult range at birth. Levels of fetal brain RRA-SMA were decreased in fetuses with different clinical disorders. In healthy newborns at cesarean section a significant correlation between serum fetal brain RRA-SMA values and birth weight and length was found. These results indicate the presence of an embryonic somatomedin in humans. The fetal brain RRA-SMA may provide a reliable index of fetal growth.
摘要
开发了一种以人胎儿脑膜为基质、生长调节素A为配体的放射受体分析法（胎儿脑RRA-SMA）。在胎儿循环中发现胎儿脑RRA-SMA水平升高。与成人相比，胎儿体内的浓度约高4倍。出生时，数值降至成人范围内。相比之下，通过生长调节素放射免疫分析法测定的成人生长调节素在胎儿体内无法检测到，且出生时低于成人范围。患有不同临床疾病的胎儿脑RRA-SMA水平降低。在剖宫产的健康新生儿中，发现血清胎儿脑RRA-SMA值与出生体重和身长之间存在显著相关性。这些结果表明人类存在一种胚胎生长调节素。胎儿脑RRA-SMA可能为胎儿生长提供可靠指标。
相似文献
1
Human embryonic somatomedin.人胚胎生长调节素
Proc Natl Acad Sci U S A. 1981 May;78(5):3175-9. doi: 10.1073/pnas.78.5.3175.
2
Measurement of somatomedin-related peptides in fetal, neonatal, and maternal rat serum by insulin-like growth factor (IGF) I radioimmunoassay, IGF-II radioreceptor assay (RRA), and multiplication-stimulating activity RRA after acid-ethanol extraction.通过胰岛素样生长因子（IGF）I放射免疫测定法、IGF-II放射受体测定法（RRA）以及酸乙醇提取后的增殖刺激活性RRA，测定胎鼠、新生鼠和母鼠血清中生长调节素相关肽。
Endocrinology. 1982 Feb;110(2):575-81. doi: 10.1210/endo-110-2-575.
3
Radioreceptor-assayable somatomedins during pregnancy and their relationship to fetal growth.孕期可通过放射受体测定的生长调节素及其与胎儿生长的关系。
J Dev Physiol. 1982 Jun;4(3):187-93.
4
Somatomedin A and B in serum from neonates, their mothers and cord blood.新生儿、其母亲血清及脐血中的生长调节素A和B。
Acta Endocrinol (Copenh). 1977 Jul;85(3):636-43. doi: 10.1530/acta.0.0850636.
5
Somatomedin in cord blood: relationship to gestational age and birth size.脐血中的生长调节素：与胎龄和出生体重的关系。
J Clin Endocrinol Metab. 1976 Dec;43(6):1378-81. doi: 10.1210/jcem-43-6-1378.
6
Somatomedin-C receptor ontogeny and levels in porcine fetal and human cord serum.猪胎儿和人脐带血清中生长调节素-C受体的个体发生及水平
J Clin Endocrinol Metab. 1976 Nov;43(5):1069-77. doi: 10.1210/jcem-43-5-1069.
7
Parturition-related changes in insulin-like growth factors-I and -II in the perinatal lamb.围产期羔羊中胰岛素样生长因子-I和-II与分娩相关的变化。
J Endocrinol. 1983 Nov;99(2):223-32. doi: 10.1677/joe.0.0990223.
8
Studies of insulin-like growth factor -I and -II by specific radioligand assays in umbilical cord blood.通过特异性放射配体分析法对脐带血中胰岛素样生长因子-I和-II进行的研究。
Clin Endocrinol (Oxf). 1983 Sep;19(3):405-13. doi: 10.1111/j.1365-2265.1983.tb00014.x.
9
Growth hormone assessment by radioreceptor and radioimmunoassay. Radioreceptor assay and radioimmunoassay comparisons.通过放射受体法和放射免疫分析法评估生长激素。放射受体分析法与放射免疫分析法的比较。
Am J Dis Child. 1984 Jan;138(1):23-7. doi: 10.1001/archpedi.1984.02140390015006.
10
Hypophysectomy of the fetal lamb leads to a fall in the plasma concentration of insulin-like growth factor I (IGF-I), but not IGF-II.切除胎羊的垂体导致胰岛素样生长因子I（IGF-I）血浆浓度下降，但胰岛素样生长因子II（IGF-II）的血浆浓度不下降。
Endocrinology. 1989 Mar;124(3):1485-91. doi: 10.1210/endo-124-3-1485.
引用本文的文献
1
Assessment of growth hormone insulin like growth factor-I axis in Down's syndrome.唐氏综合征中生长激素-胰岛素样生长因子-I轴的评估
J Endocrinol Invest. 1994 Jun;17(6):431-6. doi: 10.1007/BF03347731.
2
Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction.转铁蛋白作为一种胎儿生长因子：与胚胎诱导相关的反应性获得
Proc Natl Acad Sci U S A. 1983 May;80(9):2651-5. doi: 10.1073/pnas.80.9.2651.
3
Ontogenesis of somatomedin and insulin receptors in the human fetus.人类胎儿中生长调节素和胰岛素受体的个体发生
J Clin Invest. 1983 May;71(5):1084-94. doi: 10.1172/jci110858.
4
Characterization of somatomedins from human fetal brain: identification of a variant form of insulin-like growth factor I.人胎儿脑生长调节素的特性：胰岛素样生长因子I变异体的鉴定。
Proc Natl Acad Sci U S A. 1986 Jul;83(13):4904-7. doi: 10.1073/pnas.83.13.4904.
5
Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytes.少突胶质细胞系和新生大鼠脑少突胶质细胞的体外生长需求。
Proc Natl Acad Sci U S A. 1986 Mar;83(6):1955-9. doi: 10.1073/pnas.83.6.1955.
6
Somatomedins in tumour cyst fluid, cerebrospinal fluid, and tumour cytosol in patients with glial tumours.胶质肿瘤患者肿瘤囊液、脑脊液及肿瘤细胞溶质中的生长调节素
Acta Neurochir (Wien). 1987;89(1-2):48-52. doi: 10.1007/BF01406667.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
A new and rapid colorimetric determination of acetylcholinesterase activity.一种新的快速比色法测定乙酰胆碱酯酶活性。
Biochem Pharmacol. 1961 Jul;7:88-95. doi: 10.1016/0006-2952(61)90145-9.
3
Somatomedin A levels in serum from healthy children and from children with growth hormone deficiency or delayed puberty.健康儿童以及生长激素缺乏或青春期延迟儿童血清中的生长调节素A水平。
Acta Endocrinol (Copenh). 1980 Jun;94(2):155-65. doi: 10.1530/acta.0.0940155.
4
Serum levels of immunoreactive somatomedin A in the rat: some developmental aspects.大鼠血清中免疫反应性生长调节素A的水平：一些发育方面的情况。
Endocrinology. 1980 Aug;107(2):622-5. doi: 10.1210/endo-107-2-622.
5
Evidence that somatomedin is synthesized by multiple tissues in the fetus.有证据表明，生长调节素是由胎儿的多种组织合成的。
Dev Biol. 1980 Mar 15;75(2):315-28. doi: 10.1016/0012-1606(80)90166-9.
6
Direct mitogenic effects of human somatomedin on human embryonic lung fibroblasts.人生长调节素对人胚肺成纤维细胞的直接促有丝分裂作用。
Biochem Biophys Res Commun. 1980 Jan 29;92(2):577-85. doi: 10.1016/0006-291x(80)90372-1.
7
Depressed serum somatomedin activity in beta-thalassemia.β地中海贫血患者血清生长调节素活性降低。
J Pediatr. 1980 Feb;96(2):214-8. doi: 10.1016/s0022-3476(80)80805-5.
8
Evidence from radioligand assays that somatomedin-C and insulin-like growth factor-I are similar to each other and different from other somatomedins.放射配体分析的证据表明，生长调节素C和胰岛素样生长因子-I彼此相似，且与其他生长调节素不同。
J Clin Endocrinol Metab. 1980 Jan;50(1):206-8. doi: 10.1210/jcem-50-1-206.
9
Purification of somatomedin-C from human plasma: chemical and biological properties, partial sequence analysis, and relationship to other somatomedins.从人血浆中纯化生长调节素-C：化学和生物学特性、部分序列分析及其与其他生长调节素的关系。
Biochemistry. 1980 Feb 19;19(4):790-7. doi: 10.1021/bi00545a027.
10
Somatomedins and the fetus.生长调节素与胎儿
Clin Obstet Gynecol. 1980 Sep;23(3):765-78.
Zotero 插件