Singh Parul, Gupta Deepak Kumar, Bindra Ashish, Trikha Anjan, Lathwal Amit, Malhotra Rajesh, Walia Kamini, Mathur Purva
Department of Microbiology, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Department of Neurosurgery, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Indian J Med Microbiol. 2022 Jan-Mar;40(1):86-90. doi: 10.1016/j.ijmmb.2021.09.006. Epub 2021 Oct 1.
Increase in the antimicrobial resistance causes a concern globally. To mitigate the rapidly rising antimicrobial resistance in the health system globally antimicrobial stewardship programs (AMSP) have been advocated. Therefore, we aim to measure aggregate antibiotic consumption by both Defined Daily Dosage (DDD) and Days of Therapy (DOT) methods.
As a part of Indian Council of Medical Research initiative to develop local AMSP, this prospective study of six months was conducted at a level -1 Trauma Centre of AIIMS, New Delhi. In this, we have included all the patients of polytrauma and neurosurgical Intensive care units between April to October 2019. Consumption of antibiotics data were collected manually daily by infection control practitioners. Data were presented as Days of Therapy (DOT) and Defined Daily Dose (DDD).
During the six months of study, antimicrobial consumption of ICU was compared with empirical therapy v/s culture-based therapy. Overall average antimicrobial consumption for the six months for both empirical therapy and culture-based therapy DDD/1000 patient days was 531.8 and 460.7 whereas DOT/1000 patient days 489.9 and 426.04 respectively.
Antimicrobial Stewardship activities aim to ensure judicious consumption of antimicrobials. Such data will be of value in establishing, evaluating and monitoring the function of the AMSP in the healthcare settings.
抗菌药物耐药性的增加引起了全球关注。为缓解全球卫生系统中迅速上升的抗菌药物耐药性，抗菌药物管理计划（AMSP）已得到倡导。因此，我们旨在通过限定日剂量（DDD）和治疗天数（DOT）方法来衡量抗生素的总消耗量。
作为印度医学研究理事会制定本地AMSP倡议的一部分，这项为期六个月的前瞻性研究在新德里全印医学科学研究所的一级创伤中心进行。在此研究中，我们纳入了2019年4月至10月期间所有多发伤和神经外科重症监护病房的患者。感染控制从业人员每天手动收集抗生素消耗数据。数据以治疗天数（DOT）和限定日剂量（DDD）表示。
在六个月的研究期间，将重症监护病房的抗菌药物消耗量与经验性治疗与基于培养的治疗进行了比较。经验性治疗和基于培养的治疗六个月的总体平均抗菌药物消耗量（DDD/1000患者日）分别为531.8和460.7，而DOT/1000患者日分别为489.9和426.04。
抗菌药物管理活动旨在确保抗菌药物的合理使用。此类数据对于在医疗机构中建立、评估和监测AMSP的功能具有重要价值。
