Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2021 Sep 16;12:711540. doi: 10.3389/fendo.2021.711540. eCollection 2021.
The aim of the study was to investigate the association between the visit-to-visit variability (VVV) of fasting plasma glucose (FPG) and arterial stiffness in Chinese adults.
We performed a cohort study involving 2002 Chinese adults with no history of myocardial infarction or stroke. All the participants attended three visits (the baseline visit in 2008, the 2 visit in 2009 and the 3 visit in 2013). We used four measures to define the VVV of FPG across the three visits: the standard deviation (SD), the coefficient of variation (CV), the average successive variability (ASV) and the variability independent of the mean (VIM). We used brachial-ankle pulse wave velocity (ba-PWV) to measure arterial stiffness at the 2 and the 3 visits.
Compared with the lowest tertile of all the four measurements of VVV of FPG, significantly increased levels of ba-PWV change, ratio of ba-PWV change and the occurrence of the elevated ba-PWV were found in the highest tertile. The odds ratio (OR) and 95% confidence interval (CI) comparing participants in the highest tertile . the lowest tertile of FPG-SD was 1.37 (1.01-1.86) for risks of having elevated ba-PWV, even after adjustment for covariates including the mean FPG. Similar results were found for FPG-CV and FPG-VIM.
Greater long-term variability of FPG was associated with an increased risk of arterial stiffness, suggesting that the VVV of FPG could be used for an early detection of subclinical atherosclerosis.
本研究旨在探讨中国成年人空腹血糖（FPG）变异性与动脉僵硬之间的关系。
我们进行了一项队列研究，纳入了 2002 名无心肌梗死或卒中病史的中国成年人。所有参与者均参加了 3 次访视（2008 年基线访视、2009 年 2 次访视和 2013 年 3 次访视）。我们使用 4 种指标来定义 FPG 变异性 across the three visits：标准差（SD）、变异系数（CV）、平均连续变异性（ASV）和平均独立变异性（VIM）。我们在 2 次和 3 次访视时使用肱踝脉搏波速度（ba-PWV）来测量动脉僵硬。
与 FPG 变异性的所有 4 个指标的最低三分位相比，ba-PWV 变化幅度、ba-PWV 变化幅度比值和升高的 ba-PWV 的发生率在最高三分位明显升高。与 FPG-SD 最低三分位相比，FPG 最高三分位的参与者发生升高的 ba-PWV 的比值比（OR）和 95%置信区间（CI）为 1.37（1.01-1.86），即使在校正了包括平均 FPG 在内的混杂因素后也是如此。FPG-CV 和 FPG-VIM 也得到了类似的结果。
FPG 的长期变异性越大，动脉僵硬的风险越高，这表明 FPG 的变异性可以用于亚临床动脉粥样硬化的早期检测。
