Hobuß Lisa, Bär Christian, Thum Thomas
Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hanover, Germany.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Front Physiol. 2019 Jan 29;10:30. doi: 10.3389/fphys.2019.00030. eCollection 2019.
During the past decade numerous studies highlighted the importance of long non-coding RNAs (lncRNAs) in orchestrating cardiovascular cell signaling. Classified only by a transcript size of more than 200 nucleotides and their inability to code for proteins, lncRNAs constitute a heterogeneous group of RNA molecules with versatile functions and interaction partners, thus interfering with numerous endogenous signaling pathways. Intrinsic transcriptional regulation of lncRNAs is not only specific for different cell types or developmental stages, but may also change in response to stress factors or under pathological conditions. Regarding the heart, an increasing number of studies described the critical regulation of lncRNAs in multiple cardiac disorders, underlining their key role in the development and progression of cardiac diseases. In this review article, we will summarize functional cardiac lncRNAs with a detailed view on their molecular mode of action in pathological cardiac remodeling and myocardial infarction. In addition, we will discuss the use of circulating lncRNAs as biomarkers for prognostic and diagnostic purposes and highlight the potential of lncRNAs as a novel class of therapeutic targets for therapeutic purpose in heart diseases.
在过去十年中，大量研究突出了长链非编码RNA（lncRNAs）在协调心血管细胞信号传导中的重要性。lncRNAs仅根据转录本大小超过200个核苷酸及其无法编码蛋白质来分类，它们构成了一组具有多种功能和相互作用伙伴的异质性RNA分子，从而干扰众多内源性信号通路。lncRNAs的内在转录调控不仅针对不同细胞类型或发育阶段具有特异性，而且可能会因应激因素或在病理条件下发生变化。关于心脏，越来越多的研究描述了lncRNAs在多种心脏疾病中的关键调控作用，突显了它们在心脏病发生和发展中的关键作用。在这篇综述文章中，我们将总结功能性心脏lncRNAs，并详细阐述它们在病理性心脏重塑和心肌梗死中的分子作用模式。此外，我们将讨论循环lncRNAs作为预后和诊断生物标志物的用途，并强调lncRNAs作为心脏病治疗新一类治疗靶点的潜力。
