The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P. R. China.
Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P. R. China.
J Mater Chem B. 2021 Oct 27;9(41):8541-8557. doi: 10.1039/d1tb01661j.
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of diseases. Hydrogen (H), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (HS) acting as gas signalling molecules are representative gases in cancer therapy. They act directly on mitochondria or nuclei to lead to cell apoptosis. They can also alleviate immuno-suppression in the tumour microenvironment and promote phenotype conversion of tumour-associated macrophages. Moreover, the combination of gas therapy and other traditional therapy methods can reduce side effects and improve therapeutic efficacy. Here, we discuss the roles of NO, CO, HS and H in cancer biology. Considering the rapidly developing nanotechnology, gas-generating nanoplatforms which can achieve targeted delivery and controlled release were also discussed. Finally, we highlight the current challenges and future opportunities of gas-based cancer therapy.
气体治疗是指使用具有特殊治疗效果的某些气体来治疗疾病。氢气（H）、一氧化氮（NO）、一氧化碳（CO）和硫化氢（HS）作为气体信号分子，是癌症治疗中的代表性气体。它们直接作用于线粒体或细胞核，导致细胞凋亡。它们还可以减轻肿瘤微环境中的免疫抑制作用，并促进肿瘤相关巨噬细胞的表型转化。此外，气体治疗与其他传统治疗方法的结合可以减少副作用，提高治疗效果。在这里，我们讨论了 NO、CO、HS 和 H 在癌症生物学中的作用。考虑到快速发展的纳米技术，我们还讨论了可以实现靶向递药和控制释放的产气体纳米平台。最后，我们强调了基于气体的癌症治疗的当前挑战和未来机遇。
