The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
School of Physical Education, Xizang Minzu University, Xianyang, 712000, Shaanxi, China.
J Biomed Nanotechnol. 2022 Jan 1;18(1):24-49. doi: 10.1166/jbn.2022.3224.
The emerging area of gas-mediated cancer treatment has received widespread attention in the medical community. Featuring unique physical, chemical, and biological properties, nanomaterials can facilitate the delivery and controllable release of medicinal gases at tumor sites, and also serve as ideal platforms for the integration of other therapeutic modalities with gas therapy to augment cancer therapeutic efficacy. This review presents an overview of anti-cancer mechanisms of several therapeutic gases: nitric oxide (NO), hydrogen sulfide (H₂S), carbon monoxide (CO), oxygen (O₂), and hydrogen (H₂). Controlled release behaviors of gases under different endogenous and exogenous stimuli are also briefly discussed, followed by their synergistic effects with different therapeutic modes. Moreover, the potential challenges and future prospects regarding gas therapy based on nanomaterials are also described, aiming to facilitate the advancement of gas therapeutic nanomedicine in new frontiers for highly efficient cancer treatment.
气体介导的癌症治疗这一新兴领域在医学界受到了广泛关注。纳米材料具有独特的物理、化学和生物特性，可以促进药用气体在肿瘤部位的传递和可控释放，并且还可以作为将其他治疗模式与气体治疗相结合以增强癌症治疗效果的理想平台。本文综述了几种治疗气体（一氧化氮（NO）、硫化氢（H₂S）、一氧化碳（CO）、氧气（O₂）和氢气（H₂））的抗癌机制。还简要讨论了在不同内源性和外源性刺激下气体的控制释放行为，以及它们与不同治疗模式的协同作用。此外，还描述了基于纳米材料的气体疗法所面临的潜在挑战和未来展望，旨在促进气体治疗纳米医学在高效癌症治疗的新前沿取得进展。
