School of chemistry and chemical engineering, Nantong University, Nantong, Jiangsu 226019, China.
Dalton Trans. 2021 Feb 2;50(4):1189-1196. doi: 10.1039/d0dt03767b.
Gas therapy as a burgeoning and promising research field has attracted considerable attention in biomedicine due to its high therapeutic efficacy, biocompatibility, and biosafety. However, the lack of tumor site accumulation and controlled release of therapeutic gas molecules limited the therapeutic efficacy. Therefore, the development of gas-releasing nanoplatforms to realize tumor targeting and controllable release is highly desired. The structural diversity and tailorability and ultrahigh surface area make metal-organic frameworks (MOFs) find potential applications in the delivery and release of gas or gas releasing molecules (GRMs). In this Frontier article, we provide an overview of the recent developments achieved in gas-involving cancer therapy using MOFs or MOF-based materials. The main emphasis is focused on the design of multifunctional MOF-based nanoplatforms for the delivery and release of therapeutic gas molecules, and emphasizing their synergistic mechanism against tumor. Moreover, the challenges, future trends, and prospects of gas-related cancer therapy are also discussed.
气体治疗作为一个新兴且有前途的研究领域，由于其高效的治疗效果、生物相容性和生物安全性，在生物医药领域引起了相当大的关注。然而，治疗性气体分子在肿瘤部位的积累和控制释放的缺乏限制了其治疗效果。因此，开发释放气体的纳米平台以实现肿瘤靶向和可控释放是非常需要的。结构多样性、可定制性和超高的表面积使金属-有机骨架（MOFs）在气体或气体释放分子（GRMs）的输送和释放方面找到了潜在的应用。在这篇前沿文章中，我们综述了近年来使用 MOFs 或基于 MOF 的材料在涉及气体的癌症治疗方面所取得的进展。主要重点是设计多功能基于 MOF 的纳米平台，用于输送和释放治疗性气体分子，并强调它们对肿瘤的协同作用机制。此外，还讨论了与气体相关的癌症治疗的挑战、未来趋势和前景。
