Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
Cátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo A. C., Carretera Gustavo Enrique Astiazarán Rosas No. 46, Col. La Victoria, 83304 Hermosillo, Sonora, Mexico.
Food Funct. 2021 Nov 1;12(21):10356-10369. doi: 10.1039/d1fo02017j.
The blood-brain barrier (BBB) is a physical structure whose main function is to strictly regulate access to circulating compounds into the central nervous system (CNS). Vegetable-derived phenolic compounds have been widely studied, with numerous epidemiologic and interventional studies confirming their health-related bioactivities across multiple cells, organs and models. Phenolics are non-essential xenobiotics, and should theoretically be unable to cross the BBB. The present work summarizes current experimental evidence that reveals that not only are phenolic compounds able to cross the BBB and bioaccumulate in the brain, but there is some stereoselectivity, which suggests the presence of specific transporters that allow them to reach the brain. Some molecules cross the BBB intact, while others do so only after being biotransformed or metabolized elsewhere. Once inside the CNS, they prevent or counter oxidative stress, which maintains the molecular, cellular, structural and functional integrity of the brain, and subsequently, overall human health.
血脑屏障（BBB）是一种物理结构，其主要功能是严格调节循环化合物进入中枢神经系统（CNS）的途径。植物来源的酚类化合物已被广泛研究，大量的流行病学和干预研究证实了它们在多种细胞、器官和模型中的与健康相关的生物活性。酚类化合物是非必需的外源性物质，理论上应该无法穿过血脑屏障。目前的工作总结了现有的实验证据，表明酚类化合物不仅能够穿过血脑屏障并在大脑中积累，而且还具有一定的立体选择性，这表明存在特定的转运蛋白，使它们能够到达大脑。一些分子完整地穿过血脑屏障，而另一些分子只有在被生物转化或在其他地方代谢后才能穿过。一旦进入中枢神经系统，它们就可以预防或对抗氧化应激，从而维持大脑的分子、细胞、结构和功能的完整性，进而维持整个人类的健康。
