Liu Chen-Jian, Chen Si-Qian, Zhang Si-Yao, Wang Jia-Lun, Tang Xiao-Dan, Yang Kun-Xian, Li Xiao-Ran
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, P. R. China.
Gastroenterology Department, the First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, P. R. China.
J Microbiol. 2021 Nov;59(11):988-1001. doi: 10.1007/s12275-021-1271-9. Epub 2021 Oct 6.
Thyroid carcinoma is a common endocrine organ cancer associated with abnormal hormone secretion, leading to the disorder of metabolism. The intestinal microbiota is vital to maintain digestive and immunologic homeostasis. The relevant information of the microbial community in the gut and thyroid, including composition, structure, and relationship, is unclear in thyroid carcinoma patients. A total of 93 samples from 25 patients were included in this study. The results showed that microbial communities existed in thyroid tissue; gut and thyroid had high abundance of facultative anaerobes from the Proteobacteria phyla. The microbial metabolism from the thyroid and gut may be affected by the thyroid carcinoma cells. The cooccurrence network showed that the margins of different thyroid tissues were unique areas with more competition; the stabilization of microcommunities from tissue and stool may be maintained by several clusters of species that may execute different vital metabolism processes dominantly that are attributed to the microenvironment of cancer.
甲状腺癌是一种常见的内分泌器官癌症，与激素分泌异常相关，会导致代谢紊乱。肠道微生物群对于维持消化和免疫稳态至关重要。甲状腺癌患者肠道和甲状腺中微生物群落的相关信息，包括组成、结构及关系尚不清楚。本研究纳入了25例患者的93份样本。结果显示，甲状腺组织中存在微生物群落；肠道和甲状腺中来自变形菌门的兼性厌氧菌丰度较高。甲状腺和肠道的微生物代谢可能受甲状腺癌细胞影响。共现网络显示，不同甲状腺组织边缘是竞争更激烈的独特区域；组织和粪便中微生物群落的稳定可能由几类物种群维持，这些物种群可能主要执行不同的重要代谢过程，这归因于癌症的微环境。
