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基于Cema的高能光子束吸收剂量测定形式主义。

Cema-based formalism for the determination of absorbed dose for high-energy photon beams.

作者信息

Hartmann Günther H, Andreo Pedro, Kapsch Ralf-Peter, Zink Klemens

机构信息

Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.

出版信息

Med Phys. 2021 Nov;48(11):7461-7475. doi: 10.1002/mp.15266. Epub 2021 Oct 18.

Abstract

PURPOSE

Determination of absorbed dose is well established in many dosimetry protocols and considered to be highly reliable using ionization chambers under reference conditions. If dosimetry is performed under other conditions or using other detectors, however, open questions still remain. Such questions frequently refer to appropriate correction factors. A converted energy per mass (cema)-based approach to formulate such correction factors offers a good understanding of the specific response of a detector for dosimetry under various measuring conditions and thus an estimate of pros and cons of its application.

METHODS

Determination of absorbed dose requires the knowledge of the beam quality correction factor k , where Q denotes the quality of a user beam and Qo is the quality of the radiation used for calibration. In modern Monte Carlo (MC)-based methods, k is directly derived from the MC-calculated dose conversion factor, which is the ratio between the absorbed dose at a point of interest in water and the mean absorbed dose in the sensitive volume of an ion chamber. In this work, absorbed dose is approximated by the fundamental quantity cema. This approximation allows the dose conversion factor to be substituted by the cema conversion factor. Subsequently, this factor is decomposed into a product of cema ratios. They are identified as the stopping power ratio water to the material in the sensitive detector volume, and as the correction factor for the fluence perturbation of the secondary charged particles in the detector cavity caused by the presence of the detector. This correction factor is further decomposed with respect to the perturbation caused by the detector cavity and that caused by external detector properties. The cema-based formalism was subsequently tested by MC calculations of the spectral fluence of the secondary charged particles (electrons and positrons) under various conditions.

RESULTS

MC calculations demonstrate that considerable fluence perturbation may occur particularly under non-reference conditions. Cema-based correction factors to be applied in a 6-MV beam were obtained for a number of ionization chambers and for three solid-state detectors. Feasibility was shown at field sizes of 4 × 4 and 0.5 cm × 0.5 cm. Values of the cema ratios resulting from the decomposition of the dose conversion factor can be well correlated with detector response. Under the small field conditions, the internal fluence correction factor of ionization chambers is considerably dependent on volume averaging and thus on the shape and size of the cavity volume.

CONCLUSIONS

The cema approach is particularly useful at non-reference conditions including when solid-state detectors are used. Perturbation correction factors can be expressed and evaluated by cema ratios in a comprehensive manner. The cema approach can serve to understand the specific response of a detector for dosimetry to be dependent on (a) radiation quality, (b) detector properties, and (c) electron fluence changes caused by the detector. This understanding may also help to decide which detector is best suited for a specific measurement situation.

摘要

目的

在许多剂量测定方案中,吸收剂量的测定已得到充分确立,并且在参考条件下使用电离室被认为是高度可靠的。然而,如果在其他条件下或使用其他探测器进行剂量测定,仍然存在一些未解决的问题。这些问题经常涉及适当的校正因子。一种基于每质量转换能量(cema)的方法来制定此类校正因子,有助于很好地理解探测器在各种测量条件下的剂量测定特定响应,从而评估其应用的优缺点。

方法

吸收剂量的测定需要了解射束质量校正因子k,其中Q表示用户射束的质量,Qo是用于校准的辐射质量。在现代基于蒙特卡罗(MC)的方法中,k直接从MC计算的剂量转换因子得出,该因子是水中感兴趣点处的吸收剂量与电离室灵敏体积中的平均吸收剂量之比。在这项工作中,吸收剂量由基本量cema近似表示。这种近似允许将剂量转换因子替换为cema转换因子。随后,该因子被分解为cema比率的乘积。它们被确定为灵敏探测器体积中物质与水的阻止本领比,以及探测器存在引起的探测器腔内次级带电粒子通量扰动的校正因子。该校正因子进一步分解为由探测器腔引起的扰动和由探测器外部特性引起的扰动。随后通过MC计算在各种条件下次级带电粒子(电子和正电子)的能谱通量,对基于cema的形式主义进行了测试。

结果

MC计算表明,特别是在非参考条件下可能会发生相当大的通量扰动。针对多种电离室和三种固态探测器,获得了在6兆伏射束中应用的基于cema的校正因子。在4×4和0.5厘米×0.5厘米的射野尺寸下显示了可行性。剂量转换因子分解得到的cema比率值与探测器响应具有良好的相关性。在小射野条件下,电离室的内部通量校正因子很大程度上取决于体积平均,因此取决于腔体积的形状和大小。

结论

cema方法在包括使用固态探测器的非参考条件下特别有用。扰动校正因子可以通过cema比率以全面的方式表示和评估。cema方法有助于理解探测器剂量测定的特定响应取决于(a)辐射质量,(b)探测器特性,以及(c)探测器引起的电子通量变化。这种理解也可能有助于决定哪种探测器最适合特定的测量情况。

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