螺旋藻对亚砷酸钠诱导雄性大鼠心脏毒性的潜在保护作用。
Potential Protective Effect of Spirulina Platensis on Sodium Arsenite Induced Cardiotoxicity in Male Rats.
机构信息
College of Medicine, Mutah University, Jordan.
Faculty of Medicine, Alexandria University, Alexandria, Egypt.
出版信息
Tissue Barriers. 2022 Apr 3;10(2):1983330. doi: 10.1080/21688370.2021.1983330. Epub 2021 Oct 6.
BACKGROUND
Sodium arsenite is a dangerous bio-accumulative poison affecting a large number of people as well as animals throughout the world. It is used clinically in the treatment of certain medical conditions, but due to its harmful damage to different tissues and mainly the cardiotoxicity, its medical application is limited.
AIM
This study was conducted to investigate the protective effects of spirulina on cardiotoxicity induced by sodium arsenite biochemically and histologically.
METHODS
30 young adult male albino rats were randomly equally divided into three groups 10 animals each. Group I (control), Group II Arsenic intoxicated (10 mg/kg/day/ 4 weeks), Group III spirulina protected animals (concomitant sodium arsenite 10 mg/kg/day/ 4 weeks and spirulina 200 mg/kg/day/ 4 weeks).
RESULTS
It was evident from the study that arsenic exposure exerted a significant increase in cardiac enzyme levels, serum creatine kinase MB (CKMB) and troponin. Concomitant treatment with spirulina is considerably recovered their serum levels. Histological alterations associated with arsenite treated animals are significantly decreased after using spirulina.
CONCLUSIONS
The results of the present study showed that use of spirulina could alleviate the toxic effects on the heart following exposure to arsenic toxicity.
背景
亚砷酸钠是一种危险的生物蓄积性毒物，影响着全世界大量的人和动物。它在临床上被用于治疗某些医疗条件，但由于其对不同组织的有害损害，主要是心脏毒性，其医学应用受到限制。
目的
本研究旨在探讨螺旋藻对亚砷酸钠引起的心脏毒性的生化和组织学保护作用。
方法
30 只成年雄性白化大鼠随机平均分为三组，每组 10 只。第 I 组（对照组）、第 II 组（砷中毒组，每天 10mg/kg/4 周）、第 III 组（螺旋藻保护组，同时给予亚砷酸钠 10mg/kg/4 周和螺旋藻 200mg/kg/4 周）。
结果
研究表明，砷暴露使心肌酶水平、血清肌酸激酶 MB（CKMB）和肌钙蛋白显著升高。同时给予螺旋藻治疗可显著恢复其血清水平。用螺旋藻治疗后，与亚砷酸钠处理动物相关的组织学改变显著减少。
结论
本研究结果表明，螺旋藻的使用可以减轻砷毒性暴露后对心脏的毒性作用。
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