Neyrinck Audrey M, Taminiau Bernard, Walgrave Hannah, Daube Georges, Cani Patrice D, Bindels Laure B, Delzenne Nathalie M
Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Fundamental and Applied Research for Animal and Health (FARAH), Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.
Nutrients. 2017 Jun 20;9(6):633. doi: 10.3390/nu9060633.
Aging predisposes to hepatic dysfunction and inflammation that can contribute to the development of non-alcoholic fatty liver disease. Spirulina, a cyanobacterium used as a food additive or food supplement, has been shown to impact immune function. We have tested the potential hepatoprotective effect of a Spirulina in aged mice and to determine whether these effects can be related to a modulation of the gut microbiota. Old mice have been fed a standard diet supplemented with or without 5% Spirulina for six weeks. Among several changes of gut microbiota composition, an increase in and proportions occurs upon Spirulina treatment. Interestingly, parameters related to the innate immunity are upregulated in the small intestine of Spirulina-treated mice. Furthermore, the supplementation with Spirulina reduces several hepatic inflammatory and oxidative stress markers that are upregulated in old mice versus young mice. We conclude that the oral administration of a Spirulina is able to modulate the gut microbiota and to activate the immune system in the gut, a mechanism that may be involved in the improvement of the hepatic inflammation in aged mice. Those data open the way to new therapeutic tools in the management of immune alterations in aging, based on gut microbe-host interactions.
衰老易导致肝功能障碍和炎症，进而促使非酒精性脂肪性肝病的发展。螺旋藻是一种用作食品添加剂或食品补充剂的蓝细菌，已被证明会影响免疫功能。我们测试了螺旋藻对老年小鼠的潜在肝脏保护作用，并确定这些作用是否与肠道微生物群的调节有关。老年小鼠被喂食添加或不添加5%螺旋藻的标准饮食六周。在肠道微生物群组成的若干变化中，螺旋藻处理后，[此处原文缺失两种菌名]的比例增加。有趣的是，在经螺旋藻处理的小鼠小肠中，与先天免疫相关的参数上调。此外，补充螺旋藻可降低老年小鼠与年轻小鼠相比上调的几种肝脏炎症和氧化应激标志物。我们得出结论，口服螺旋藻能够调节肠道微生物群并激活肠道免疫系统，这一机制可能参与改善老年小鼠的肝脏炎症。这些数据为基于肠道微生物与宿主相互作用来管理衰老过程中免疫改变的新治疗工具开辟了道路。
