Lim Ji-Hoon, Sim Woo-Young, Lew Bark-Lynn
Department of Medicine, Graduate School, Kyung Hee University, Seoul, Korea.
Ann Dermatol. 2021 Oct;33(5):459-462. doi: 10.5021/ad.2021.33.5.459. Epub 2021 Sep 8.
Sweet's syndrome was first described as a reactive dermatosis characterized by sudden onset of fever, leukocytosis, and erythematous plaques infiltrated with neutrophils. Therefore, Sweet's syndrome is also known as acute febrile neutrophilic dermatosis. However, subsequently, it became clear that fever and neutrophilia in Sweet's syndrome vary depending on the case, and several other characteristics have been described. The lesions in Sweet's syndrome are typically observed not only in the limbs but also in the face, neck, and upper trunk. A 28-year-old female without a specific medical history presented in a hospital following the complaint of painful erythematous patches and pustules on her palms and soles. She had no previous history of palmoplantar pustulosis and other infections or malignancies. A skin biopsy showed diffuse dermal infiltration of neutrophils. Laboratory tests showed increased neutrophil count and erythrocyte sedimentation rate. After systemic corticosteroid administration was initiated, the lesions gradually disappeared. The patient was subsequently diagnosed with Sweet's syndrome according to histology, clinical feature, and response to treatment. However, there have been few reports of Sweet's syndrome confined to the individuals' palms and soles. According to the literatures, although the dorsum of the hand is frequently affected, the palmoplantar involvement as in our case appears to be rare.
斯威特综合征最初被描述为一种反应性皮肤病，其特征为突然发热、白细胞增多以及伴有中性粒细胞浸润的红斑斑块。因此，斯威特综合征也被称为急性发热性嗜中性皮病。然而，随后发现斯威特综合征中的发热和嗜中性粒细胞增多因病例而异，并且还描述了其他一些特征。斯威特综合征的皮损通常不仅见于四肢，也见于面部、颈部和上躯干。一名28岁无特殊病史的女性因手掌和足底出现疼痛性红斑斑块和脓疱而到医院就诊。她既往无掌跖脓疱病及其他感染或恶性肿瘤病史。皮肤活检显示真皮内中性粒细胞弥漫浸润。实验室检查显示中性粒细胞计数和红细胞沉降率升高。开始全身应用糖皮质激素后，皮损逐渐消失。随后根据组织学、临床特征及治疗反应，该患者被诊断为斯威特综合征。然而，局限于手掌和足底的斯威特综合征报道很少。根据文献，尽管手背常受累，但像我们病例中手掌和足底受累的情况似乎很罕见。
