Polman Jeremy, Reddy Sainandan, Williams Aaron C, DeWitt Aaron
Internal Medicine Residency Program, Baton Rouge General, Baton Rouge, Louisiana, USA.
Case Rep Gastroenterol. 2021 May 25;15(2):470-474. doi: 10.1159/000516210. eCollection 2021 May-Aug.
Budd-Chiari syndrome (BCS) is an uncommon illness that is characterized by obstruction of hepatic venous outflow. Patients typically present with nausea, vomiting, and abdominal pain, which can further progress into signs associated with liver failure, including jaundice, encephalopathy, and coagulopathy. The most common causes of BCS include pathologies that induce portal vein thrombosis, such as myeloproliferative disorders, malignancy, and acquired hypercoagulable states. In this case report, a patient who presented with abdominal pain and distention is diagnosed with BCS caused by an unusual etiology. He was found to have significant eosinophilia, prompting additional evaluation for parasitic infections. Using stool diagnostics/studies, he was found to have trophozoites. The patient was treated with enoxaparin, warfarin, and metronidazole with a resolution of his symptoms. This case outlines a novel cause of BCS as well as the proposed mechanism of induction of BCS.
布加综合征(BCS)是一种罕见疾病,其特征为肝静脉流出道梗阻。患者通常表现为恶心、呕吐和腹痛,这些症状可进一步发展为与肝衰竭相关的体征,包括黄疸、脑病和凝血功能障碍。BCS最常见的病因包括导致门静脉血栓形成的病变,如骨髓增殖性疾病、恶性肿瘤和获得性高凝状态。在本病例报告中,一名出现腹痛和腹胀的患者被诊断为由不寻常病因引起的BCS。发现他有明显的嗜酸性粒细胞增多症,促使对寄生虫感染进行进一步评估。通过粪便诊断/检查,发现他有滋养体。该患者接受了依诺肝素、华法林和甲硝唑治疗,症状得到缓解。本病例概述了BCS的一种新病因以及BCS的诱发机制。