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E2F1 诱导的长非编码 RNA BAIAP2-AS1 过表达通过 miR-361-3p/SOX4 轴促进肝癌的恶性进展。

E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis.

机构信息

Department of Clinical Laboratory, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Haizhou District, Lianyungang, China.

Department of Surgery, The Qingdao Eighth People's Hospital, Qingdao, Shandong, China.

出版信息

Dis Markers. 2021 Sep 25;2021:6256369. doi: 10.1155/2021/6256369. eCollection 2021.

DOI:10.1155/2021/6256369
PMID:34616498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8487846/
Abstract

Currently, plenty of researches have revealed that long noncoding RNAs (lncRNAs) can act as crucial roles during the progression of various tumors, including hepatocellular carcinoma (HCC). Here, we measured the expression of lncRNA BAIAP2 antisense RNA 1(BAIAP2-AS1) as well as its contribution to the developments of HCC. In this study, the expressions of BAIAP2-AS1 and SOX4 were distinctly upregulated in HCC cells and tissues, and high BAIAP2-AS1 may be a novel biomarker for HCC. E2F1 activated BAIAP2-AS1 expression. The silence of BAIAP2-AS1 inhibited the proliferation and metastasis of HepG2 and PLC5 cells. Assays for relationship verification showed that BAIAP2-AS1 regulated the expression of SOX4 and miR-361-3p. Rescue experiments further confirmed the positive interaction between miR-361-3p and BAIAP2-AS1 as well as between miR-361-3p and SOX4. Overall, BAIAP2-AS1 modulated the miR-361-3p/SOX4 axis to promote the development of HCC. Thus, our study offers a potential therapeutic target for treating HCC.

摘要

目前，大量研究表明长链非编码 RNA（lncRNA）在包括肝细胞癌（HCC）在内的各种肿瘤的进展中可以发挥关键作用。在这里，我们测量了 lncRNA BAIAP2 反义 RNA 1（BAIAP2-AS1）的表达及其对 HCC 发展的贡献。在这项研究中，BAIAP2-AS1 和 SOX4 的表达在 HCC 细胞和组织中明显上调，高表达的 BAIAP2-AS1 可能是 HCC 的一种新型生物标志物。E2F1 激活 BAIAP2-AS1 的表达。沉默 BAIAP2-AS1 抑制 HepG2 和 PLC5 细胞的增殖和转移。关系验证实验表明，BAIAP2-AS1 调节 SOX4 和 miR-361-3p 的表达。进一步的挽救实验证实了 miR-361-3p 和 BAIAP2-AS1 之间以及 miR-361-3p 和 SOX4 之间的正相互作用。总的来说，BAIAP2-AS1 调节了 miR-361-3p/SOX4 轴，促进了 HCC 的发展。因此，我们的研究为治疗 HCC 提供了一个潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/b65ba65f4cb8/DM2021-6256369.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/d5d7736c3195/DM2021-6256369.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/b2dc39ab9375/DM2021-6256369.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/b65ba65f4cb8/DM2021-6256369.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/d5d7736c3195/DM2021-6256369.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/78217c39de22/DM2021-6256369.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/e0dd38ffcb0c/DM2021-6256369.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/13825b3f25d6/DM2021-6256369.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/88065b46fa40/DM2021-6256369.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/e5d604620b8b/DM2021-6256369.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/b2dc39ab9375/DM2021-6256369.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363d/8487846/b65ba65f4cb8/DM2021-6256369.008.jpg

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