Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, China.
Institute of Urology, Anhui Medical University, Hefei 230000, China.
Biomed Res Int. 2021 Sep 27;2021:6525449. doi: 10.1155/2021/6525449. eCollection 2021.
We search the PubMed, Embase, Google Scholar, and Wanfang (China) databases (up to December 1, 2020) to identify all eligible publications. The pooled odds ratio (OR) correspondence with 95% confidence interval (CI) was calculated to evaluate the associations.
Finally, nine eligible studies with 7,157 cases and 6,440 controls and five studies with 2,278 cases and 2,821 controls were enrolled in rs3877899 and rs7579 polymorphisms, individually. However, a null significant association was detected between the two polymorphisms in and susceptibility to colorectal, breast, and prostate cancer in all comparison models. Subsequently, subgroup analysis based on tumor type, no significant association was identified for prostate, breast, and colorectal cancer. In addition, when the stratification analyses were conducted by the source of control, HWE status, and ethnicity, yet no significant association was found.
The current meta-analysis shows that SEPP1 rs3877899 and rs7579 polymorphisms may not be associated with susceptibility to colon cancer, breast cancer, and prostate cancer, and further well-designed studies with a larger sample size are warranted to validate our findings.
我们检索了 PubMed、Embase、Google Scholar 和万方（中国）数据库（截至 2020 年 12 月 1 日），以确定所有符合条件的出版物。使用合并的优势比（OR）和 95%置信区间（CI）来评估相关性。
最终，我们纳入了 rs3877899 和 rs7579 多态性的 9 项符合条件的研究，其中包括 7157 例病例和 6440 例对照，以及 5 项研究，其中包括 2278 例病例和 2821 例对照。然而，在所有比较模型中，这两个多态性与结直肠癌、乳腺癌和前列腺癌的易感性之间均未检测到显著关联。随后，基于肿瘤类型的亚组分析也未发现前列腺癌、乳腺癌和结肠癌与这两个多态性之间存在显著关联。此外，当按对照来源、HWE 状态和种族进行分层分析时，也未发现显著关联。
目前的荟萃分析表明，SEPP1 rs3877899 和 rs7579 多态性可能与结直肠癌、乳腺癌和前列腺癌的易感性无关，需要进一步进行设计良好、样本量更大的研究来验证我们的发现。
