两种不同抗氧化剂组合对精子参数的影响。

The effects of two different antioxidant combinations on sperm parameters.

作者信息

Yaris Mehmet, Akdogan Nebil, Öztürk Murat, Bozkurt Aliseydi, Karabakan Mehmet

机构信息

Department of Urology, Genesis Private Hospital, Diyarbakir, Turkey.

Department of Urology, Faculty of Medicine, Cukurova University, Adana, Turkey.

出版信息

Urologia. 2022 Nov;89(4):629-635. doi: 10.1177/03915603211049888. Epub 2021 Oct 7.

DOI:10.1177/03915603211049888

PMID:34617487

Abstract

BACKGROUND

Studies demonstrate that getting antioxidants in the course of treatment has a positive impact beneficial effect on fertility, especially on the quality of sperm. Because of that reason antioxidants are recommended as a potentially influential treatment for infertility in men. However, it is argued that this treatment is not based on sufficient evidence and has no effect on the rate of healthy pregnancy.

OBJECTIVE

In this study, two different antioxidant combinations with different doses and contents were evaluated in terms of their effect on sperm parameters.

MATERIALS/METHODS: A total of 122 patients diagnosed with idiopathic infertility were enrolled in our multicenter study. The patients were divided into two different groups: The first group used a combination 2 × 1 sachet form (l-carnitine 1 g, acetyl-l-carnitine 0.5 g, fructose 1 g, citric acid 0.50 mg, selenium 50 µg, coenzyme Q10 20 mg, vitamin C 90 mg, zinc 10 mg, folic acid 200 µg, and vitamin B12 1.5 µg) and the second group used a combination tablets form 2 × 1 (l-carnitine 500 mg, selenium 50 µg, coenzyme Q10 20 mg, vitamin C 60 mg, zinc 15 mg, folic acid 400 µg, vitamin E, and ginseng 15 µg) for 6 months. The total semen volume, the total sperm number, sperm concentration, sperm motility, and lastly morphological findings of the patients were compared at the end of 6 months.

RESULTS

The mean age of the patients participating in the study was 30.8 ± 6.05 years. No significant difference was found between the two groups in terms of baseline sperm count. There was a significant difference between the baseline and sixth-month values of the patients using both combinations. However, no significant statistical difference was found between the groups according to the sixth-month data. The combinations of both antioxidants had a positive effect on sperm parameters, and the use of different doses and contents had a similar effect.

CONCLUSION

Both antioxidants respectively had a positive effect on sperm parameters and also the use of different doses and contents had a similar effect.

摘要

背景

研究表明，在治疗过程中摄入抗氧化剂对生育能力有积极影响，尤其对精子质量有益。因此，抗氧化剂被推荐作为一种可能对男性不育有影响的治疗方法。然而，有人认为这种治疗方法缺乏充分证据，对健康怀孕率没有影响。

目的

在本研究中，评估了两种不同剂量和成分的抗氧化剂组合对精子参数的影响。

材料/方法：共有122名被诊断为特发性不育的患者参与了我们的多中心研究。患者被分为两组：第一组使用2×1包形式的组合（左旋肉碱1克、乙酰左旋肉碱0.5克、果糖1克、柠檬酸0.50毫克、硒50微克、辅酶Q10 20毫克、维生素C 90毫克、锌10毫克、叶酸200微克和维生素B12 1.5微克），第二组使用2×1片形式（左旋肉碱500毫克、硒50微克、辅酶Q10 20毫克、维生素C 60毫克、锌15毫克、叶酸400微克、维生素E和人参15微克），持续6个月。在6个月末比较患者的精液总体积、精子总数、精子浓度、精子活力以及最后的形态学结果。