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系统性红斑狼疮患者 COVID-19 疫苗接种后与眼部不良事件的时间关联:病例报告。

An ocular adverse event in temporal association with COVID-19 vaccination in a patient with systemic lupus erythematosus: a case report.

机构信息

College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.

出版信息

Hum Vaccin Immunother. 2021 Nov 2;17(11):4102-4104. doi: 10.1080/21645515.2021.1976036. Epub 2021 Oct 7.

Abstract

After the COVID-19 pandemic, vaccines using inactivated viruses have attracted worldwide attention for the prevention of infectious diseases. Here, we report a patient who suffered from Systemic Lupus Erythematosus (SLE) for six years and developed ocular symptoms within 72 hours after being vaccinated for COVID-19. The patient presented bilateral conjunctival congestion, eyelid edema with pruritus, and suffered from severe headaches. Recovery occurred within 10 days after the onset of symptoms after treatment with anti-infection drugs. The early identification and extensive assessment of side effects help ensuring effective vaccine safety monitoring.

摘要

在 COVID-19 大流行之后,用于预防传染病的灭活病毒疫苗引起了全球关注。在这里,我们报告了一位患有系统性红斑狼疮 (SLE) 六年的患者,在接种 COVID-19 疫苗后 72 小时内出现眼部症状。患者表现为双眼结膜充血、眼睑水肿伴瘙痒,并伴有严重头痛。在开始出现症状后 10 天内,经抗感染药物治疗后症状缓解。早期识别和广泛评估副作用有助于确保有效的疫苗安全性监测。

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本文引用的文献

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Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China.中国医护人员中灭活 SARS-CoV-2 疫苗的安全性。
Expert Rev Vaccines. 2021 Jul;20(7):891-898. doi: 10.1080/14760584.2021.1925112. Epub 2021 May 13.
2
Ocular adverse events following vaccination: overview and update.接种疫苗后的眼部不良事件:概述和更新。
Surv Ophthalmol. 2022 Mar-Apr;67(2):293-306. doi: 10.1016/j.survophthal.2021.04.001. Epub 2021 Apr 16.
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Update: Vaccines in primary immunodeficiency.更新:原发性免疫缺陷病中的疫苗。
J Allergy Clin Immunol. 2018 Feb;141(2):474-481. doi: 10.1016/j.jaci.2017.12.980. Epub 2017 Dec 27.
7
Ocular manifestations in systemic lupus erythematosus.系统性红斑狼疮的眼部表现
Br J Ophthalmol. 2016 Jan;100(1):135-41. doi: 10.1136/bjophthalmol-2015-306629. Epub 2015 Apr 22.

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