Public Laboratory, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China.
Evidence-based Medicine Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, China.
Expert Rev Vaccines. 2021 Jul;20(7):891-898. doi: 10.1080/14760584.2021.1925112. Epub 2021 May 13.
: Although the inactivated SARS-CoV-2 vaccine (CoronaVac) has undergone preclinical tests and clinical trials evaluating its efficacy and safety, few data have been reported in the post-licensure real-world setting. We aimed to assess the safety of the vaccine among healthcare workers.: A self-administered online survey on monitoring adverse reactions post vaccination was conducted among the staff who worked at and were vaccinated in a tertiary hospital in Taizhou, China, from February 24 to 7 March 2021. A total of 1526 subjects responded to the questionnaire when they received an e-mail or an e-poster on WeChat.: The incidences of overall adverse reactions after the first and second injections were 15.6% (238/1526) and 14.6% (204/1397), respectively. The most common adverse reaction was localized pain at the injection site, with an incidence of 9.6% and 10.7% after each dose, accounting for 61.8% and 73.0% of adverse reactions, respectively. Fatigue, muscle pain, and headache were the most common systemic adverse reactions.: These findings implied that the inactivated CoronaVac vaccine has an acceptable safety profile among healthcare workers due to the low incidence of self-reported adverse reactions. This may boost public confidence in nationwide mass vaccination campaigns.
: 虽然已对灭活的 SARS-CoV-2 疫苗（科兴疫苗）进行了临床前测试和临床试验，以评估其疗效和安全性，但在上市后的真实环境中报告的数据很少。我们旨在评估该疫苗在医护人员中的安全性。: 2021 年 2 月 24 日至 3 月 7 日，在中国台州的一家三级医院工作并接种疫苗的医护人员通过自我管理的在线问卷调查，对疫苗接种后的不良反应进行监测。: 当他们收到电子邮件或微信电子海报时，共有 1526 名受试者回答了问卷。: 第一针和第二针后的总体不良反应发生率分别为 15.6%（238/1526）和 14.6%（204/1397）。最常见的不良反应是注射部位局部疼痛，每次剂量的发生率分别为 9.6%和 10.7%，分别占不良反应的 61.8%和 73.0%。疲劳、肌肉疼痛和头痛是最常见的全身不良反应。: 这些发现表明，由于报告的不良反应发生率低，灭活的科兴疫苗在医护人员中的安全性良好。这可能会增强公众对全国性大规模疫苗接种运动的信心。
