局部注射平阳霉素和博来霉素治疗黄色瘤的动物实验研究。
Animal experimental research of intralesional bleomycin and pingyangmycin in the treatment of xanthoma.
机构信息
Department of Plastic and Reconstructive Surgery, Changzheng Hospital, Navy Medical University (Second Military Medical University), Shanghai, China.
Department of Plastic and reconstructive surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
出版信息
J Cosmet Dermatol. 2022 Jul;21(7):2977-2983. doi: 10.1111/jocd.14500. Epub 2021 Oct 7.
BACKGROUND
Xanthelasma palpebrarum is a type of human xanthoma that occurs on the skin of human eyelids and is a benign skin lesion. Pingyangmycin (also known as bleomycin A5) is one of the 13 components of bleomycin. The aim of this study was to explore the efficacy of intralesional bleomycin and pingyangmycin in the treatment of xanthoma based on histopathological observations in animal experimental research.
METHODS
An animal model of xanthoma was established by feeding rabbits with a high-cholesterol diet. Pingyangmycin and bleomycin interfered with the skin xanthoma of the animal model. Skin tissue specimens were stained with hematoxylin-eosin and oil red O to evaluate the effect of the intervention.
RESULTS
A xanthoma animal model was established. Pingyangmycin and bleomycin could reduce the abnormal lipid deposition in the lesion area of the skin xanthoma of the animal, via a local injection. In addition, pingyangmycin was more effective than bleomycin in eliminating lipid deposition in rabbit skin xanthoma.
背景
睑黄瘤是一种发生于人体眼睑皮肤的人类黄色瘤，属于良性皮肤病变。平阳霉素（亦称争光霉素 A5）是博莱霉素 13 种成分之一。本研究旨在通过动物实验研究的组织病理学观察，探讨平阳霉素局部注射治疗黄色瘤的疗效。
方法
通过给予兔子高胆固醇饮食建立黄色瘤动物模型。平阳霉素和博莱霉素干预动物模型的皮肤黄色瘤，采用苏木精-伊红及油红 O 染色评估干预效果。
结果
成功建立黄色瘤动物模型。平阳霉素和博莱霉素局部注射均可减少皮肤黄色瘤病灶区异常脂质沉积。另外，平阳霉素消除兔皮肤黄色瘤脂质沉积的效果优于博莱霉素。
Zotero 插件