the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
School of Mechanical and Electrical Engineering, Qingdao University, Qingdao 266071, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Feb 5;266:120458. doi: 10.1016/j.saa.2021.120458. Epub 2021 Sep 29.
Near-infrared (NIR) photothermal therapy is an effective partner to the chemotherapy of tumors with the merits of high therapeutic ability and slight side effect on normal tissues. Herein, we synthesized gold nanorods and assembled them with L-cysteine reduced graphene oxide (AuNR@Lcyst-rGO) for efficient photothermal therapy. The high therapeutic efficacy of AuNR@Lcyst-rGO can be due to the high photothermal effect of gold nanorods and reduced graphene oxide, and the synergistic effect of them. The nontoxicity of L-cysteine also guarantees the comfortable biocompatibility of reduced graphene oxide, which is essential for the photothermal absorber used in human tissue. The results demonstrate that assembly of gold nanorods with reduced graphene oxide (AuNR@Lcyst-rGO) is a promising photothermal agent with high efficient NIR-triggered photothermal therapy efficiency, excellent stability, superior biocompatibility.
近红外（NIR）光热疗法是肿瘤化疗的有效伙伴，具有治疗能力高和对正常组织副作用小的优点。在此，我们合成了金纳米棒，并将其与 L-半胱氨酸还原氧化石墨烯（AuNR@Lcyst-rGO）组装，以实现高效的光热治疗。AuNR@Lcyst-rGO 的高效治疗效果可能归因于金纳米棒和还原氧化石墨烯的高光热效应，以及它们的协同作用。L-半胱氨酸的无毒性质也保证了还原氧化石墨烯的舒适生物相容性，这对于用于人体组织的光热吸收剂至关重要。结果表明，金纳米棒与还原氧化石墨烯的组装（AuNR@Lcyst-rGO）是一种很有前途的光热剂，具有高效的 NIR 触发光热治疗效率、优异的稳定性和卓越的生物相容性。
