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氧化石墨烯模板金纳米片作为高效近红外热疗剂用于癌症治疗。

Graphene Oxide-Template Gold Nanosheets as Highly Efficient Near-Infrared Hyperthermia Agents for Cancer Therapy.

机构信息

NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, People's Republic of China.

Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, People's Republic of China.

出版信息

Int J Nanomedicine. 2020 Oct 29;15:8451-8463. doi: 10.2147/IJN.S265134. eCollection 2020.

DOI:10.2147/IJN.S265134
PMID:33149586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7605662/
Abstract

INTRODUCTION

Near-infrared (NIR) hyperthermia agents are promising in cancer photothermal therapy due to their deeper penetration ability and less side effects. Spherical gold nanoshell and graphene-based nanomaterials are two major NIR hyperthermia agents that have been reported for photothermal therapy of cancer. Herein, we constructed a two-dimensional graphene oxide-template gold nanosheet (GO@SiO@AuNS) hybrid that could destruct cancer cells with efficient photothermal effect.

METHODS

Graphene oxide was coated with a layer of mesoporous silica, which provided binding sites for gold seeds. Then, seed-growth method was utilized to grow a layer of gold nanosheet to form the GO@SiO@AuNS hybrid, which possessed great biocompatibility and high photothermal conversion efficiency.

RESULTS

With the irradiation of NIR laser (808 nm) with low power density (0.3 W/cm), GO@SiO@AuNS hybrid showed a photothermal conversion efficiency of 30%, leading to a temperature increase of 16.4 °C in water. Colorectal cancer cells (KM12C) were killed with the treatment of GO@SiO@AuNS hybrid under NIR irradiation.

CONCLUSION

The GO@SiO@AuNS hybrid may expand the library of the 2D nanostructures based on gold for cancer photothermal therapy.

摘要

简介

近红外（NIR）光热治疗剂由于其更深的穿透能力和更少的副作用，在癌症光热治疗中很有前途。球形金纳米壳和基于石墨烯的纳米材料是两种主要的 NIR 光热治疗剂，已被报道用于癌症的光热治疗。在此，我们构建了一种二维氧化石墨烯模板金纳米片（GO@SiO@AuNS）杂化物，它可以通过有效的光热效应破坏癌细胞。

方法

氧化石墨烯被涂覆了一层介孔硅，为金种子提供了结合位点。然后，采用种子生长法在氧化石墨烯上生长了一层金纳米片，形成了 GO@SiO@AuNS 杂化物，具有很好的生物相容性和高光热转换效率。

结果

在低功率密度（0.3 W/cm）的 NIR 激光（808nm）照射下，GO@SiO@AuNS 杂化物表现出 30%的光热转换效率，导致水中温度升高 16.4°C。在 NIR 照射下，GO@SiO@AuNS 杂化物处理的结直肠癌细胞（KM12C）被杀死。

结论

GO@SiO@AuNS 杂化物可能会扩展基于金的二维纳米结构在癌症光热治疗中的应用库。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fa/7605662/5a3721f4155f/IJN-15-8451-g0012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fa/7605662/e71c4d646a53/IJN-15-8451-g0006.jpg
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