Tan C T, de Sousa M, Tan R, Hansen J A, Good R A
Cancer Res. 1978 Apr;38(4):886-93.
Over the past 5 years, parameters of immunological function have been determined in all children with biopsy-proven Hodgkin's disease in the Department of Pediatrics, Memorial Sloan-Kettering Cancer Center. This report summarizes the in vitro responses of lymphocytes to stimulation by mitogens and antigens (between January 1975 and December 1976) in 33 of these previously untreated patients. In nine of these patients, responses of the splenic lymphocytes were studied concomitantly with the responses of peripheral blood lymphocytes. Peripheral blood from normal children and adults was used as the control. Our results have demonstrated no significant differences between the responses of normal children and adult controls. The absolute necessity for concomitant studies of the controls and the patients was shown. The value of examining multiple concentrations of a single mitogen was also well defined. In the children with Hodgkin's disease, there was a consistent failure of the peripheral blood lymphocytes to respond to the lower concentration dose of phytohemagglutinin. However, this abnormality was not found in the splenic lymphocytes.
在过去5年里，纪念斯隆-凯特琳癌症中心儿科对所有经活检证实患有霍奇金病的儿童进行了免疫功能参数测定。本报告总结了1975年1月至1976年12月期间33例此前未经治疗的此类患者淋巴细胞对有丝分裂原和抗原刺激的体外反应。其中9例患者，同时研究了脾淋巴细胞反应和外周血淋巴细胞反应。正常儿童和成人的外周血用作对照。我们的结果表明，正常儿童和成人对照的反应之间无显著差异。结果显示了对照和患者同时研究的绝对必要性。单一有丝分裂原多种浓度检测的价值也得到了明确界定。在患有霍奇金病的儿童中，外周血淋巴细胞对较低浓度剂量的植物血凝素始终无反应。然而，在脾淋巴细胞中未发现这种异常。
