霍奇金病患者的脾脏淋巴细胞群体——不同密度细胞的特性
Spleen lymphocyte populations in patients with Hodgkin's disease--properties of cells with different densities.
作者信息
Rocha B, Ferreira A A, Munn G, de Sousa M, Freitas A A
出版信息
Clin Exp Immunol. 1982 May;48(2):300-6.
Abstract
Spleen lymphocytes from five patients with Hodgkin's disease (HD) type mixed cellularity and five normal controls were studied. An increased percentage of 'null cells' was observed in three out of the five patients studied. The two other patients had increased percentage of T lymphocytes. Lymphocytes from spleen with HD had a decreased ability to respond to suboptimal concentrations of T cell mitogens. When these cells were fractionated in a discontinuous density gradient a subpopulation of cells, unable to respond to Con A, was recovered from the dense cell fractions. The implications of the present findings to the understanding of the physiopathological changes in HD are discussed.
摘要
对5例混合型细胞性霍奇金病（HD）患者和5名正常对照者的脾脏淋巴细胞进行了研究。在所研究的5例患者中，有3例观察到“裸细胞”百分比增加。另外2例患者的T淋巴细胞百分比增加。HD患者脾脏中的淋巴细胞对次优浓度T细胞有丝分裂原的反应能力下降。当这些细胞在不连续密度梯度中进行分级分离时，从高密度细胞级分中回收了一群无法对刀豆球蛋白A作出反应的细胞。讨论了本研究结果对理解HD生理病理变化的意义。
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本文引用的文献
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Studies on delayed hypersensitivity in Hodgkin's disease.霍奇金病迟发型超敏反应的研究。
J Clin Invest. 1962 Nov;41(11):1964-70. doi: 10.1172/JCI104654.
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An investigation of Hodgkin's disease with respect to the problem of homotransplantation.关于同种移植问题对霍奇金病的一项研究。
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Human lymphocyte traffic assessed by indium-111 oxine labelling: clinical observations.通过铟-111 氧肟酸标记评估人类淋巴细胞转运：临床观察
Clin Exp Immunol. 1981 Mar;43(3):443-9.
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Reed-Sternberg cells in Hodgkin's disease contain fibronectin.霍奇金病中的里德-施特恩伯格细胞含有纤连蛋白。
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Mechanism of T cell activation. I. A screening of "step one" ligands.T细胞活化机制。I. “第一步”配体的筛选。
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Two distinct factors are required for induction of T-cell growth.诱导T细胞生长需要两个不同的因素。
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The selective elimination of immunologically competent cells from bone marrow and lymphocyte cell mixtures. 3. In vitro test for detection of immunocompetent cells in fractionated mouse spleen cell suspensions and primate bone marrow suspensions.从骨髓和淋巴细胞混合液中选择性清除免疫活性细胞。3. 检测分级分离的小鼠脾细胞悬液和灵长类动物骨髓悬液中免疫活性细胞的体外试验。
Transplantation. 1969 Oct;8(4):422-34. doi: 10.1097/00007890-196910000-00014.
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Response of human thymus-derived (T) and non-thymus-derived (B) lymphocytes to mitogenic stimulation in vitro.人胸腺来源的（T）淋巴细胞和非胸腺来源的（B）淋巴细胞在体外对有丝分裂原刺激的反应。
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J Clin Invest. 1973 Jul;52(7):1726-34. doi: 10.1172/JCI107354.
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