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粪便微生物移植与膳食纤维补充，相得益彰？

Fecal microbiota transplantation and fiber supplementation, better together?

机构信息

Amsterdam Diabetes Centrum, Internal and Vascular Medicine, Location AMC, Amsterdam UMC, 1105 AZ Amsterdam, Netherlands.

出版信息

Cell Rep Med. 2021 Sep 23;2(9):100403. doi: 10.1016/j.xcrm.2021.100403. eCollection 2021 Sep 21.

DOI:10.1016/j.xcrm.2021.100403
PMID:34622239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8484686/
Abstract

Fecal microbiota transplantation (FMT) is emerging as a tool to study the microbiome and as a potential treatment for several non-infectious diseases. Recently, Mocanu et al. showed that supplementing low fermentable fiber after FMT may improve insulin sensitivity in severely obese individuals..

摘要

粪便微生物群移植（FMT）正在成为一种研究微生物组的工具，并可能成为几种非传染性疾病的潜在治疗方法。最近，Mocanu 等人表明，在 FMT 后补充低可发酵纤维可能会改善严重肥胖个体的胰岛素敏感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dde4/8484686/5a9b12bc145f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dde4/8484686/5a9b12bc145f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dde4/8484686/5a9b12bc145f/gr1.jpg

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Fecal microbiota transplantation and fiber supplementation, better together?粪便微生物移植与膳食纤维补充，相得益彰？
Cell Rep Med. 2021 Sep 23;2(9):100403. doi: 10.1016/j.xcrm.2021.100403. eCollection 2021 Sep 21.
2
Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial.严重肥胖和代谢综合征患者的粪便微生物移植和纤维补充：一项随机、双盲、安慰剂对照的 2 期试验。
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本文引用的文献

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Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial.严重肥胖和代谢综合征患者的粪便微生物移植和纤维补充：一项随机、双盲、安慰剂对照的 2 期试验。
Nat Med. 2021 Jul;27(7):1272-1279. doi: 10.1038/s41591-021-01399-2. Epub 2021 Jul 5.
2
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?人类代谢性疾病中的粪便微生物群移植：从模糊的过去走向光明的未来？
Cell Metab. 2021 Jun 1;33(6):1098-1110. doi: 10.1016/j.cmet.2021.05.005.
3
Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study.
超重或肥胖供者的粪便微生物移植在晚期胃食管癌症恶病质患者中的应用：一项随机、双盲、安慰剂对照的 II 期研究。
Clin Cancer Res. 2021 Jul 1;27(13):3784-3792. doi: 10.1158/1078-0432.CCR-20-4918. Epub 2021 Apr 21.
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Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients.粪便微生物移植克服了黑色素瘤患者对抗 PD-1 治疗的耐药性。
Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363.
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Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain.饮食调节的自体粪菌移植对体重反弹的影响。
Gastroenterology. 2021 Jan;160(1):158-173.e10. doi: 10.1053/j.gastro.2020.08.041. Epub 2020 Aug 26.
6
Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients.供体粪便微生物群移植可改善异基因造血细胞移植受者的肠道移植物抗宿主病。
Sci Transl Med. 2020 Aug 12;12(556). doi: 10.1126/scitranslmed.aaz8926.
7
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time.供体代谢特征驱动粪菌移植对受体胰岛素敏感性、能量消耗和肠道转运时间的影响。
Gut. 2020 Mar;69(3):502-512. doi: 10.1136/gutjnl-2019-318320. Epub 2019 May 30.
8
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