锌和钙在胰腺β细胞中胰岛素形成与储存过程中的作用。 - Suppr

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Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell.

作者信息

Howell S L, Tyhurst M, Duvefelt H, Andersson A, Hellerström C

出版信息

Cell Tissue Res. 1978 Mar 31;188(1):107-18. doi: 10.1007/BF00220518.

DOI:10.1007/BF00220518

PMID:346226

Abstract

摘要

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Role of zinc and calcium in the formation and storage of insulin in the pancreatic beta-cell.锌和钙在胰腺β细胞中胰岛素形成与储存过程中的作用。

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Complete nucleotide sequence of a Coxsackievirus B-4 strain capable of establishing persistent infection in human pancreatic islet cells: effects on insulin release, proinsulin synthesis, and cell morphology.一种能够在人胰岛细胞中建立持续感染的柯萨奇病毒B-4株的完整核苷酸序列：对胰岛素释放、胰岛素原合成及细胞形态的影响

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A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of Langerhans.一种用于研究胰岛中胰岛素释放机制和钙代谢的亚细胞分级分离方法。

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The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.甲苯磺丁脲和格列本脲对分离的胰岛中（3H）亮氨酸掺入及胰岛素原向胰岛素转化的影响。

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Imatinib prevents beta cell death in vitro but does not improve islet transplantation outcome.伊马替尼可在体外预防β细胞死亡，但不能改善胰岛移植结果。

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Zinc and insulin metabolism.锌与胰岛素代谢。

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Insulin granule biogenesis, trafficking and exocytosis.胰岛素颗粒的生物合成、运输与胞吐作用。

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Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway.胰岛素原的内切蛋白酶解作用可增强加工后的胰岛素靶向调节性分泌途径的能力。

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Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.胰腺β细胞未成熟分泌颗粒内蛋白质分选的独特分子机制。

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Influence of sulfonylureas on the secretion, disposal and effect of insulin.磺脲类药物对胰岛素分泌、代谢及作用的影响。

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Role of zinc in insulin biosynthesis. Some possible zinc-insulin interactions in the pancreatic B-cell.锌在胰岛素生物合成中的作用。胰腺β细胞中一些可能的锌 - 胰岛素相互作用。

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Changes in histochemically detectable calcium and zinc during tolbutamide-induced degranulation and subsequent regranulation of rat pancreatic islets.甲苯磺丁脲诱导大鼠胰岛脱颗粒及随后再颗粒化过程中组织化学可检测的钙和锌的变化。

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Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.分离出的胰岛素分泌颗粒的低分子量成分。二价阳离子、腺嘌呤核苷酸和无机磷酸盐。

Biochem J. 1983 Feb 15;210(2):297-305. doi: 10.1042/bj2100297.

本文引用的文献

Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans.葡萄糖浓度对使用分离的哺乳动物胰岛将[3H]亮氨酸掺入胰岛素的影响。

Biochim Biophys Acta. 1966 Dec 28;130(2):519-21. doi: 10.1016/0304-4165(66)90250-9.

Isolation and properties of secretory granules from rat islets of Langerhans. 3. Studies of the stability of the isolated beta granules.大鼠胰岛分泌颗粒的分离与特性。3. 分离的β颗粒稳定性研究。

J Cell Biol. 1969 Apr;41(1):167-76. doi: 10.1083/jcb.41.1.167.

Isolation and properties of secretory granules from rat islets of Langerhans. II. Ultrastructure of the beta granule.大鼠胰岛分泌颗粒的分离与特性。II. β颗粒的超微结构。

J Cell Biol. 1969 Apr;41(1):162-6. doi: 10.1083/jcb.41.1.162.

Physicochemical characteristics of insulin secretion granules.胰岛素分泌颗粒的物理化学特性。

Biochem J. 1969 Jan;111(1):107-13. doi: 10.1042/bj1110107.

Determination of total serum insulin (IRI) in insulin-treated diabetic patients.胰岛素治疗的糖尿病患者血清总胰岛素（IRI）的测定。

Diabetologia. 1972 Aug;8(4):260-6. doi: 10.1007/BF01225569.

The significance of calcium in insulin secretion. Ultrastructural studies on identification and localization of calcium in activated and inactivated B cells of mice.钙在胰岛素分泌中的意义。对小鼠活化和失活B细胞中钙的鉴定和定位的超微结构研究。

Virchows Arch A Pathol Anat Histol. 1974;362(3):231-45. doi: 10.1007/BF00432197.

The electron microscopic localization of cations to pancreatic islets of Langerhans and their possible tole in insulin secretion.阳离子在胰岛中的电子显微镜定位及其在胰岛素分泌中的可能作用。

J Ultrastruct Res. 1973 Feb;42(3):298-311. doi: 10.1016/s0022-5320(73)90058-0.

Metabolic characteristics of isolated pancreatic islets in tissue culture.组织培养中分离的胰岛的代谢特征

Diabetes. 1972;21(2 Suppl):546-54. doi: 10.2337/diab.21.2.s546.

Role of ATP in the intracellular translocation of proinsulin and insulin in the rat pancreatic B cell.

Nat New Biol. 1972 Jan 19;235(55):85-6. doi: 10.1038/newbio235085a0.

Solubilizing effect of nucleotides on isolated insulin secretory granules.核苷酸对分离的胰岛素分泌颗粒的增溶作用。

J Cell Biol. 1970 Oct;47(1):289-93. doi: 10.1083/jcb.47.1.289.

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