Ogino M, Jimbo T
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Jul;38(7):1120-4.
Plasma levels of PGE2 and PGF2 alpha were determined in women from 24 to 40 weeks of pregnancy with non-pregnant women as controls. The plasma levels of PGE2 showed no significant changes as gestation advanced except for late pregnancy only. Furthermore, there were no significant differences observed between the control and pregnant subjects except late in pregnancy. On the other hand, the concentrations of PGF2 alpha in the pregnant subjects revealed a significant increase (p less than 0.005) compared with those of the controls, though no significant changes were observed with the advance of gestation except for late pregnancy. The PGF2 alpha/PGE2 ratio showed a six to ten times rise during pregnancy (p less than 0.005) compared with that of the controls. Therefore, the results obtained in the present study may explain the effectiveness of prostaglandin synthetase inhibitors in suppressing preterm uterine contraction and they also indicate the involvement of some factors in the initiation and inhibition of the myometrium contraction.
以非孕妇作为对照，测定了妊娠24至40周女性的血浆PGE2和PGF2α水平。除妊娠晚期外，随着妊娠进展，PGE2的血浆水平无显著变化。此外，除妊娠晚期外，对照组和妊娠组之间未观察到显著差异。另一方面，与对照组相比，妊娠组中PGF2α的浓度显著升高（p<0.005），尽管除妊娠晚期外，随着妊娠进展未观察到显著变化。与对照组相比，PGF2α/PGE2比值在妊娠期间升高了6至10倍（p<0.005）。因此，本研究获得的结果可能解释了前列腺素合成酶抑制剂在抑制早产子宫收缩方面的有效性，并且它们还表明某些因素参与了子宫肌层收缩的起始和抑制。
