Centro Científico Tecnológico (CCT) La Plata- CONICET, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, República Argentina.
Centro de Investigaciones Opticas, La Plata, República Argentina.
PLoS One. 2021 Oct 8;16(10):e0255894. doi: 10.1371/journal.pone.0255894. eCollection 2021.
In this work we study the characteristics of heart rate variability (HRV) as a function of age and gender. Our analysis covers a wider age range than that studied so far. It includes results previously reported in the literature and reveals behaviours not reported before. We can establish basic scale relationships in different HRV measurements. The mean value of the RR intervals shows a power-law behaviour independent of gender. Magnitudes such as the standard deviation or pNN50 show abrupt changes at around the age of 12 years, and above that age they show gender dependence, which mainly affects short-time (or high frequency) scales. We present a unified analysis for the calculation of the non-linear α and β parameters. Both parameters depend on age; they increase in the extremes of life and reach a minimum at around one year of age. These gender-independent changes occur at low frequencies and in scale ranges that depend on age. The results obtained in this work are discussed in terms of the effects of basal metabolic rate, hormonal regulation, and neuronal activity on heart rate variability. This work finally discusses how these findings influence the interpretation of HRV measurements from records of different lengths.
在这项工作中，我们研究了心率变异性（HRV）随年龄和性别变化的特征。我们的分析涵盖了比以往研究更广泛的年龄范围。它包括了以前在文献中报道的结果，并揭示了以前没有报道过的行为。我们可以在不同的 HRV 测量中建立基本的比例关系。RR 间隔的平均值表现出与性别无关的幂律行为。幅度，如标准差或 pNN50，在大约 12 岁左右会发生突然变化，而在这个年龄之后，它们表现出性别依赖性，这主要影响短时间（或高频）尺度。我们提出了一种统一的分析方法来计算非线性α和β参数。这两个参数都取决于年龄；它们在生命的极端增加，并在大约一岁时达到最小值。这些与性别无关的变化发生在低频和依赖于年龄的尺度范围内。我们将从基础代谢率、激素调节和神经元活动对心率变异性的影响方面讨论这项工作中获得的结果。最后，本文还讨论了这些发现如何影响对不同长度记录的 HRV 测量的解释。
