Baron J A, Byers T, Greenberg E R, Cummings K M, Swanson M
J Natl Cancer Inst. 1986 Sep;77(3):677-80. doi: 10.1093/jnci/77.3.677.
This case-control study addressed the relationship between cigarette smoking and cancers of the breast (1,741 cases), endometrium (476 cases), uterine cervix (1,174 cases), and ovary (296 cases). The lifetime smoking history of cases was compared with that of 2,128 controls, and relative risks (odds ratios) for smoking were estimated using multiple logistic regression to adjust for potential confounding by age, marital status, number of pregnancies, and Quetelet's index. With increasing amount smoked there was a statistically significant decrease in endometrial cancer risk and a statistically significant increase in cervical cancer risk. In the highest smoking category (greater than or equal to 15 pack-yr), the endometrial cancer relative risk was 0.57 [95% confidence interval (CI) of 0.37, 0.86] and the cervical cancer relative risk was 1.81 (95% CI of 1.47, 2.22). There was no apparent relationship between smoking and cancers of the breast or ovary.
这项病例对照研究探讨了吸烟与乳腺癌（1741例）、子宫内膜癌（476例）、子宫颈癌（1174例）和卵巢癌（296例）之间的关系。将病例的终生吸烟史与2128名对照者的吸烟史进行比较，并使用多元逻辑回归估计吸烟的相对风险（比值比），以调整年龄、婚姻状况、怀孕次数和体重指数等潜在混杂因素。随着吸烟量的增加，子宫内膜癌风险在统计学上显著降低，而子宫颈癌风险在统计学上显著增加。在最高吸烟类别（大于或等于15包年）中，子宫内膜癌相对风险为0.57[95%置信区间（CI）为0.37,0.86]，子宫颈癌相对风险为1.81（95%CI为1.47,2.22）。吸烟与乳腺癌或卵巢癌之间没有明显关系。
