Grützmeier S, von Schenck H
Med Oncol Tumor Pharmacother. 1986;3(2):71-5. doi: 10.1007/BF02934556.
C-reactive protein, CRP, was followed longitudinally in 41 patients being treated for acute leukemia. It was analysed by a rapid (2-h) immunochemical assay in a laser-nephelometer. The cytostatic treatment given either intravenously or intrathecally did not cause any CRP increase with the exception of 7% of the treatment courses, given to 3 patients, and neither did transfusion reactions. The patients had altogether 117 febrile episodes. During 44 episodes with evidence of bacterial or fungal infection, CRP increased above the reference value (90 mg l-1). The same observation was made during 37 febrile episodes with clinically probable infections. CRP remained within the reference value when fever was caused by virus infections or occurring for unknown reasons.
对41例接受急性白血病治疗的患者进行了C反应蛋白（CRP）的纵向跟踪。采用激光散射比浊法通过快速（2小时）免疫化学分析对其进行检测。无论是静脉内还是鞘内给予的细胞抑制治疗，除了给予3例患者的7%的治疗疗程外，均未导致CRP升高，输血反应也未导致CRP升高。这些患者共有117次发热发作。在44次有细菌或真菌感染证据的发作期间，CRP升高超过参考值（90 mg/l）。在37次临床上可能存在感染的发热发作期间也观察到了同样的情况。当发热由病毒感染引起或原因不明时，CRP保持在参考值范围内。
