Rintala E, Irjala K, Nikoskelainen J
Department of Medicine, Turku University Central Hospital, Finland.
Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):973-8. doi: 10.1007/BF01967785.
The maximum serum levels of C-reactive protein (CRP) in 126 patients with hematological malignancies who had 554 febrile episodes were analyzed retrospectively with regard to documented infections and fever of unknown origin. The CRP levels were significantly higher when the blood culture was positive than when it was negative (p = 0.002). The CRP levels were significantly higher when the infection focus was identified than when it was not (p = 0.010). In patients with fever of unknown origin the CRP was significantly lower than in patients with microbiologically documented infections (p < 0.001). Cytotoxic treatment neither reduced nor enhanced the CRP reaction. The serial measurement of CRP is a reliable and readily available means for differentiating between bacterial infections and other causes of fever in patients with hematological malignancies, also during neutropenia and after cytotoxic treatment.
回顾性分析了126例血液系统恶性肿瘤患者554次发热发作时的血清C反应蛋白（CRP）最高水平，这些患者存在记录在案的感染和不明原因发热。血培养阳性时的CRP水平显著高于血培养阴性时（p = 0.002）。确定感染灶时的CRP水平显著高于未确定感染灶时（p = 0.010）。不明原因发热患者的CRP水平显著低于微生物学确诊感染的患者（p < 0.001）。细胞毒性治疗既未降低也未增强CRP反应。连续测定CRP是区分血液系统恶性肿瘤患者细菌感染与其他发热原因的可靠且易于获得的方法，在中性粒细胞减少期间和细胞毒性治疗后也是如此。
