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3D 打印技术在支架开发中的进展。

3D printing advances in the development of stents.

机构信息

School of Science, University of Greenwich, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK; CIPER Centre for Innovation and Process Engineering Research, Kent ME4 4TB, UK.

Mathematical Modelling for Engineering Research Group, Department of Engineering Science, University of Greenwich, UK.

出版信息

Int J Pharm. 2021 Nov 20;609:121153. doi: 10.1016/j.ijpharm.2021.121153. Epub 2021 Oct 5.

Abstract

3D printing technologies have found several applications within the biomedical sector including in the fabrication of medical devices, advanced visualization, diagnosis planning and simulation of surgical procedures. One of the areas in which of 3D printing is anticipated to revolutionised is the manufacturing of implantable bioresorbable drug-eluting scaffolds (stents). The ability to customize and create personalised tailor-made bioresorbable scaffolds has the potential to help solve many of the challenges associated with stenting, such as inappropriate stent sizing and design, abolish late stent thrombosis and help artery growth; 3D printing offers a rapid prototyping and effective method of producing stents making customization of designs feasible. This review provides an overview of the subjects and summarizes the latest research in the 3D printing technologies employed for the design and fabrication of bioresorbable stents including materials with the required printable and mechanical properties. Finally, we present a regulatory perspective on the development and engineering of 3D printed implantable stents.

摘要

3D 打印技术在生物医学领域有多种应用,包括医疗器械制造、高级可视化、诊断规划和手术模拟。预计 3D 打印将彻底改变的一个领域是可植入生物可吸收药物洗脱支架(支架)的制造。定制和创建个性化定制生物可吸收支架的能力有可能帮助解决与支架相关的许多挑战,例如支架尺寸和设计不当、消除晚期支架血栓形成并帮助动脉生长;3D 打印提供了一种快速原型制作和生产支架的有效方法,使设计的定制成为可能。本综述概述了主题,并总结了用于设计和制造生物可吸收支架的 3D 打印技术的最新研究,包括具有所需可打印和机械性能的材料。最后,我们从监管角度介绍了 3D 打印植入式支架的开发和工程。

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