Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.
Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, Madrid, Spain.
Psychoneuroendocrinology. 2021 Nov;133:105429. doi: 10.1016/j.psyneuen.2021.105429. Epub 2021 Sep 24.
Consumption of high-fat diets (HFD) has been associated with neuronal plasticity deficits and cognitive disorders linked to the alteration of glutamatergic disorders in the hippocampus. As young individuals are especially vulnerable to the effects of nutrients and xenobiotics on cognition, we studied the effect of chronic consumption of saturated (SOLF) and unsaturated oil-enriched foods (UOLF) on: i) spatial memory; ii) hippocampal synaptic transmission and plasticity; and iii) gene expression of glutamatergic receptors and hormone receptors in the hippocampus of adolescent and adult mice. Our results show that both SOLF and UOLF impair spatial short-term memory. Accordingly, hippocampal synaptic plasticity mechanisms underlying memory, and gene expression of NMDA receptor subunits are modulated by both diets. On the other hand, PPARγ gene expression is specifically down-regulated in adolescent SOLF individuals and up-regulated in adult UOLF mice.
高脂肪饮食（HFD）的摄入与神经元可塑性缺陷以及与海马谷氨酸能紊乱相关的认知障碍有关。由于年轻人特别容易受到营养物质和外源性物质对认知的影响，我们研究了慢性摄入饱和（SOLF）和不饱和油富集食物（UOLF）对以下方面的影响：i）空间记忆；ii）海马突触传递和可塑性；以及 iii）海马中谷氨酸能受体和激素受体的基因表达在青少年和成年小鼠中。我们的结果表明，SOLF 和 UOLF 都损害了空间短期记忆。因此，记忆的海马突触可塑性机制以及 NMDA 受体亚基的基因表达均受这两种饮食的调节。另一方面，PPARγ 基因表达在青少年 SOLF 个体中特异性地下调，而在成年 UOLF 小鼠中上调。
