Milan Gabriella, Conci Scilla, Sanna Marta, Favaretto Francesca, Bettini Silvia, Vettor Roberto
Department of Medicine, University of Padua, Internal Medicine 3, 35128 Padua, Italy; Center for the Study and the Integrated Treatment of Obesity, Padua Hospital, 35128 Padua, Italy.
Department of Medicine, University of Padua, Internal Medicine 3, 35128 Padua, Italy; Center for the Study and the Integrated Treatment of Obesity, Padua Hospital, 35128 Padua, Italy.
Trends Endocrinol Metab. 2021 Dec;32(12):994-1006. doi: 10.1016/j.tem.2021.09.001. Epub 2021 Oct 5.
We describe adipose stromal/stem cells (ASCs) in the structural/functional context of the adipose tissue (AT) stem niche (adiponiche), including cell-cell interactions and the microenvironment, and emphasize findings obtained in humans and in lineage-tracing models. ASCs have distinctive markers, 'colors', and anatomical 'locations' which influence their functions. Each adiponiche component can become impaired, thereby contributing to the pathological AT alterations seen in obesity and metabolic diseases. We discuss adiposopathy with a focus on adiponiche dysfunction, and underline the mechanisms that control AT expansion and energy balance. Better understanding of adiponiche regulation and ASC features could help to identify therapeutic targets that favor weight loss and counteract weight regain, and also contribute to innovative strategies for regenerative medicine.
我们在脂肪组织（AT）干细胞生态位（脂肪生态位）的结构/功能背景下描述脂肪间充质/干细胞（ASC），包括细胞间相互作用和微环境，并强调在人类和谱系追踪模型中获得的发现。ASC具有独特的标志物、“特征”和解剖学“位置”，这些会影响其功能。脂肪生态位的每个组成部分都可能受损，从而导致肥胖和代谢疾病中出现的病理性AT改变。我们以脂肪生态位功能障碍为重点讨论脂肪病，并强调控制AT扩张和能量平衡的机制。更好地理解脂肪生态位调节和ASC特征有助于确定有利于减肥和防止体重反弹的治疗靶点，也有助于推动再生医学的创新策略。
