Hariharan Harini, Kesavan Yasodha, Raja Natesan Sella
MPI Lab, Department of Genetic Engineering, SRM Institute of Science and Technology, Chengalpattu, India.
Mol Biol Rep. 2021 Nov;48(11):7559-7573. doi: 10.1007/s11033-021-06733-y. Epub 2021 Oct 9.
Exosomes are minuscule vesicles secreted in the endolytic region of most mammalian cells. The release of exosomes from the cell engenders cell-to-cell signaling between cellular-compartments. The trading of exosomes between tumor and yonder cells plays a hypercritical role in tumor growth and progression. The exosome released from each tumor cell sequestrates a unique biogenetic pathway reflecting its cellular origin depending on the tumor type. However, treatment of tumor cells with certain physiological factors like drugs, chemotherapy, radiation, etc., enhance the release of exosomes and alters its biogenetic pathway compared with untreated tumor cells. In this review, we will discuss how the non-native physiological factors influence the release of exosomes and how these reactive exosomes orchestrate a unique patterning of a cargo sorting mechanism. We will also discuss the role of reactively secreted exosomes in mediating tumor metastasis, angiogenesis, and tumor progression.
外泌体是大多数哺乳动物细胞在内溶区域分泌的微小囊泡。外泌体从细胞中释放会引发细胞间区室之间的细胞间信号传导。肿瘤细胞与远处细胞之间外泌体的交换在肿瘤生长和进展中起着至关重要的作用。每个肿瘤细胞释放的外泌体都有一条独特的生物发生途径，反映其细胞起源，这取决于肿瘤类型。然而，与未处理的肿瘤细胞相比，用某些生理因素如药物、化疗、辐射等处理肿瘤细胞会增加外泌体的释放并改变其生物发生途径。在这篇综述中，我们将讨论非天然生理因素如何影响外泌体的释放，以及这些反应性外泌体如何精心编排独特的货物分选机制模式。我们还将讨论反应性分泌的外泌体在介导肿瘤转移、血管生成和肿瘤进展中的作用。
