Department of Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.
Division of Pediatric Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, New York, USA.
Int J Paediatr Dent. 2022 Jul;32(4):558-575. doi: 10.1111/ipd.12934. Epub 2022 Feb 6.
To conduct a systematic review and to evaluate the clinical parameters for periodontal diseases in individuals with cleft lip and/or palate (CL/P).
The authors searched six indexed databases without any linguistic limitation through July 2021. The eligibility criteria were observational studies that compared the periodontal clinical measures of individuals with CL/P to those without CL/P. A meta-analysis was conducted using random-effects models with inverse variance weighting.
The literature search generated 1277 records, and 40 full-text articles were reviewed. Twenty-three studies comprising 3235 individuals from four continents fulfilled our selection criteria. The meta-analysis revealed a significant difference in mean plaque index scores (MD = 0.31, 95% CI = 0.22, 0.41), gingival index scores (MD = 0.50, 95% CI = 0.24, 0.77), and periodontal pocket depth (MD = 0.64, 95% CI = 0.12, 1.16) between individuals with and without CL/P. A slight increase in clinical attachment loss was detected among individuals with CL/P; however, such an increase may have little clinical significance.
As age is positively related to periodontal disease progression, and individuals with CL/P are more likely to present with more plaque accumulation and gingival inflammation, clinicians should reinforce preventive dental care from an early age.
系统回顾并评估唇腭裂（CL/P）患者的牙周病临床参数。
作者于 2021 年 7 月前在六个索引数据库中进行了无语言限制的检索。纳入标准为比较唇腭裂患者与非唇腭裂患者牙周临床指标的观察性研究。使用具有逆方差加权的随机效应模型进行荟萃分析。
文献检索产生了 1277 条记录，对 40 篇全文文章进行了审查。来自四大洲的 23 项研究共纳入 3235 名患者符合我们的选择标准。荟萃分析显示，唇腭裂患者的平均菌斑指数评分（MD=0.31，95%CI=0.22，0.41）、牙龈指数评分（MD=0.50，95%CI=0.24，0.77）和牙周袋深度（MD=0.64，95%CI=0.12，1.16）存在显著差异。唇腭裂患者的临床附着丧失略有增加，但这种增加可能没有临床意义。
由于年龄与牙周病进展呈正相关，且唇腭裂患者更易出现菌斑堆积和牙龈炎症，因此临床医生应从早期开始加强预防性口腔护理。
