不再是一招鲜：STING 信号转导活动超越干扰素。
No Longer A One-Trick Pony: STING Signaling Activity Beyond Interferon.
机构信息
Center for Immunotherapy & Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, United States.
Department of Immunology, University of Texas Southwestern Medical Center, United States.
出版信息
J Mol Biol. 2022 Mar 30;434(6):167257. doi: 10.1016/j.jmb.2021.167257. Epub 2021 Oct 8.
Abstract
Stimulator of interferon genes (STING) plays an important role in infection, autoimmune disease and cancer. STING-mediated type I interferon (IFN) signaling is well recognized and extensively studied. Several IFN-independent activities of STING were also discovered in recent years and their physiological importance has begun to be appreciated. Here, we review recent advance in the evolutionary origin and molecular mechanisms of STING-mediated IFN-independent activities. New insights from these studies suggest that STING is not just a simple IFN-producing machine, rather, it functions as a hub that converts multiple environmental cues into diverse cellular responses . This expanded view of STING biology should guide future clinical testing of STING agonists in cancer and treatment of STING-associated human diseases.
摘要
干扰素基因刺激物 (STING) 在感染、自身免疫性疾病和癌症中发挥重要作用。STING 介导的 I 型干扰素 (IFN) 信号通路已得到广泛认可和深入研究。近年来，还发现了 STING 的几种 IFN 非依赖性活性，其生理重要性开始受到重视。本文综述了 STING 介导的 IFN 非依赖性活性的进化起源和分子机制的最新进展。这些研究的新见解表明，STING 不仅仅是一个简单的 IFN 产生机器，而是作为一个枢纽，将多种环境线索转化为多种细胞反应。对 STING 生物学的这种扩展观点应指导未来在癌症中对 STING 激动剂的临床测试和治疗与 STING 相关的人类疾病。
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