Park Hee-Seon, Seo Chang-Seob, Baek Eun Bok, Rho Jin-Hyung, Won Young-Suk, Kwun Hyo-Jung
Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
Evid Based Complement Alternat Med. 2021 Sep 29;2021:9968112. doi: 10.1155/2021/9968112. eCollection 2021.
The flavonoid myricetin is abundant in vegetables and has various bioactive properties, including anti-inflammatory and antioxidative activities. In the present study, we explored the effects of myricetin on alcohol-induced gastric ulcer in a rat model. To induce gastric ulcer, absolute ethanol (5 mL/kg body weight) was orally administrated to each rat. The positive control and myricetin-treated groups were given oral doses of omeprazole (20 mg/kg) or myricetin (12 mg/kg), respectively, 1 hour prior to the administration of absolute alcohol. We found that pretreatment with myricetin significantly decreased alcohol-induced gastric ulcer, hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Myricetin pretreatment reduced the level of malondialdehyde (MDA) and increased that of total glutathione (GSSG/GSH) and superoxide dismutase (SOD) in gastric tissues. In addition, it elevated the expression levels of cyclooxygenase-1 (COX-1) and prostaglandin E (PGE) and decreased the phosphorylation of nuclear factor kappa B (NF-B). Together, these results indicate that myricetin effectively inhibits ethanol-induced acute gastric injury by preventing oxidative damage, stimulating PGE production, and inhibiting NF-B activation. We suggest that myricetin may be an alternative treatment for gastric injury caused by alcohol intake.
黄酮类化合物杨梅素在蔬菜中含量丰富，具有多种生物活性，包括抗炎和抗氧化活性。在本研究中，我们在大鼠模型中探究了杨梅素对酒精诱导的胃溃疡的影响。为诱导胃溃疡，给每只大鼠口服绝对乙醇（5毫升/千克体重）。在给予绝对乙醇前1小时，阳性对照组和杨梅素处理组分别口服奥美拉唑（20毫克/千克）或杨梅素（12毫克/千克）。我们发现，杨梅素预处理显著降低了酒精诱导的胃溃疡、出血、充血以及胃黏膜上皮细胞损失。杨梅素预处理降低了胃组织中丙二醛（MDA）水平，提高了总谷胱甘肽（GSSG/GSH）和超氧化物歧化酶（SOD）水平。此外，它提高了环氧化酶-1（COX-1）和前列腺素E（PGE）的表达水平，并降低了核因子κB（NF-κB）的磷酸化。这些结果共同表明，杨梅素通过防止氧化损伤、刺激PGE产生和抑制NF-κB激活，有效抑制了乙醇诱导的急性胃损伤。我们认为，杨梅素可能是酒精摄入所致胃损伤的一种替代治疗方法。
