Blanco-Gandia M Carmen, Montagud-Romero Sandra, Rodríguez-Arias Marta
Department of Psychology and Sociology, University of Zaragoza, Teruel 44003, Spain.
Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Valencia 46010, Spain.
World J Psychiatry. 2021 Sep 19;11(9):517-529. doi: 10.5498/wjp.v11.i9.517.
Many of the various factors, characteristics, and variables involved in the addictive process can determine an individual's vulnerability to develop drug addiction. Hedonic eating, based on pleasure rather than energy needs, modulates the same reward circuits, as do drugs of abuse. According to the last report of the World Health Organization, the worldwide obesity rate has more than doubled since 1980, reaching especially critical levels in children and young people, who are overexposed to high-fat, high-sugar, energy-dense foods. Over the past few decades, there has been an increase in the number of studies focused on how eating disorders can lead to the development of drug addiction and on the comorbidity that exists between the two disorders. Herein, we review the most recent research on the subject, focusing especially on animal models of binge eating disorders and drug addiction. The complex profile of patients with substance use and binge eating disorders requires an integrated response to dually diagnosed patients. Nutritional patterns should be considered an important variable in the treatment of substance use disorders, and future studies need to focus on specific treatments and interventions in individuals who show a special vulnerability to shift from one addiction to the other.
成瘾过程中涉及的许多不同因素、特征和变量都可能决定个体对药物成瘾的易感性。基于愉悦而非能量需求的享乐性进食会调节与滥用药物相同的奖赏回路。根据世界卫生组织的最新报告,自1980年以来,全球肥胖率增加了一倍多,在过度接触高脂肪、高糖、高能量食物的儿童和年轻人中尤其达到了危急水平。在过去几十年里,专注于饮食失调如何导致药物成瘾以及这两种疾病之间共病情况的研究数量有所增加。在此,我们回顾了关于该主题的最新研究,尤其关注暴饮暴食症和药物成瘾的动物模型。物质使用和暴饮暴食症患者的复杂情况需要对双重诊断患者采取综合应对措施。营养模式应被视为物质使用障碍治疗中的一个重要变量,未来的研究需要关注对表现出从一种成瘾转向另一种成瘾特殊易感性的个体的具体治疗和干预措施。